BT564 Structure Elucidation Methods İn Bioctive Molecules

8 ECTS - 4-0 Duration (T+A)- . Semester- 4 National Credit

Information

Code BT564
Name Structure Elucidation Methods İn Bioctive Molecules
Term 2024-2025 Academic Year
Semester . Semester
Duration (T+A) 4-0 (T-A) (17 Week)
ECTS 8 ECTS
National Credit 4 National Credit
Teaching Language Türkçe
Level Yüksek Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator


Course Goal / Objective

The objective of this course, it is aimed to teach the methods used in elucidating the structure of bioactive molecules and the techniques applied in these methods together with the strategies for elucidating the structure of bioactive molecules

Course Content

Molecular spectroskopy, Electromagnetic Spektrum, UV-Visible Spectroscopy, UV-Absorption bands of some pharmaceutical and chromophore groups, Applications of IR-spectroscopy in bioactive compounds, Interpretation of IR-Spectrums, IR-Spectroscopy in the Identification of functional groups in drug or bioactive molecules, Raman spektroscopy, Nuclear Magnetıc Resonance (NMR) Spectroscopy, Chemical Shift and Spin-Spin Interactions, Multiplicity of the signal, 1H-NMR 13C-NMR, 2D-COSY, DEPT, HETCOR, NOESY ve nOe differences techniques, . Interpretation of NMR Spectrums, Use of NMR spectroscopy for structure elucidation of bioactive and drug molecules, MS Spectrometry, Spectrums evaluation and use of structural determination in drug and bioactive molecules. Single crystal X-ray spectroscopy and its use in structure determination, Use of Combined Spectral Analysis Methods in the analysis of drugs, bioorganic and bioactive compounds. Identification of stereochemistry in bioactive molecules. Determination of chirality in bioactive molecules

Course Precondition

Not required

Resources

Horst Friebolin Transl. by Jack Becconsall Basic One-and-Two-dimensional NMR spectroscopy, 1993 Pavia DL., Lampman GM., Kriz GS. Introduction to Spectroscopy , Saunders College Publishing, 1979 lremore, I.R., Evaluation of Instrumentation for UV-Visible Spectrophotometry, J. Chem. Educ., 63 : A, 216, 1986 Nakanishi, K., Infrared Absorption Spectroscopy, 2nd ed., San Fransisco, Holden Day, 1997 Kar, A, Pharmaceutical Drug Analysis, New Age Int. Publishers, 2005 Williams H. D., Fleming I. Spectroscopic methods in organic chemistry. Fourth Edt. Revised, McGraw-Hill Book Company, England, 1989 Balcı M. Nükleer manyetik rezonans Spektroskopisi. ODTÜ Geliştirme Vakfı Yayıncılık ve İletişim A.Ş. Birinci Baskı, Ankara, 2000 De Hoffmann E., Stoobant V. Mass Spectroscopy. Newyork, John wiley Sons, Second Ed. 2001 Rene E. Van Grieken, Andrzej A. Markowicz, Handbook of X-ray spectrometry: methods and techniques, 1993 Manz, Pamme, N., Lossfidis, Bioanalytical Chemistry, Imperial colege Press, 2003 Erdik, E; Organik Kimyada Spektroskopik Yöntemler, 3. Baskı, Gazi Kitapevi, 2005

Notes

Lecture notes


Course Learning Outcomes

Order Course Learning Outcomes
LO01 To know and recognize bioactive molecules
LO02 To knows and use analytical techniques in structure elucidation in bioactive molecules.
LO03 To get knowledge and comprehend the strategies followed in elucidating the structure of drugs and drug intermediates
LO04 To know the combined spectral analysis methods and use them in drugs and bioactive molecules characterization


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. 5
PLO02 Beceriler - Bilişsel, Uygulamalı To identifiy the interdisciplinary interaction of the field and to solve use of the methods.
PLO03 Beceriler - Bilişsel, Uygulamalı Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information 4
PLO04 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Develops new strategic approaches for solving complex problems that are encountered in applications related to the field.
PLO05 Yetkinlikler - Öğrenme Yetkinliği To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. 3
PLO06 Yetkinlikler - İletişim ve Sosyal Yetkinlik To solve the problems encountered in the field and cominicate by using research methods.
PLO07 Yetkinlikler - Alana Özgü Yetkinlik To gain the ability to develop and deepen the knowledge in the field of biotechnology
PLO08 Yetkinlikler - Alana Özgü Yetkinlik Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field.
PLO09 Yetkinlikler - Öğrenme Yetkinliği Knows the ethical rules to be considered while obtaining biotechnological products.
PLO10 Yetkinlikler - İletişim ve Sosyal Yetkinlik He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field.


Week Plan

Week Topic Preparation Methods
1 Molecular spectroskopy Books and scientific database Öğretim Yöntemleri:
Anlatım, Tartışma, Soru-Cevap, Bireysel Çalışma
2 Electromagnetic Spectrum, UV-Visible Spectroscopy Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
3 UV-Absorption bands of some pharmaceutical and chromophore groups Books and scientific database Öğretim Yöntemleri:
Anlatım, Tartışma, Soru-Cevap
4 Applications of IR-spectroscopy in bioactive compounds Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
5 Interpretation of IR-Spectrums, IR-Spectroscopy in the Identification of functional groups in drug or bioactive molecules Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
6 Raman spektroscopy Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
7 Nuclear Magnetıc Resonance (NMR) Spectroscopy Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
8 Chemical Shift and Spin-Spin Interactions, Multiplicity of the signal Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
9 1H-NMR 13C-NMR, 2D-COSY, DEPT, HETCOR, NOESY and nOe techniques Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
10 Interpretation of NMR Spectrums Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
11 Use of NMR spectroscopy for structure elucidation of bioactive and drug molecules Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
12 MS Spectrometry, Spectrums evaluation and use of structural determination in drug and bioactive molecules Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
13 Single crystal X-ray spectroscopy and its use in structure determination Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
14 Use of Combined Spectral Analysis Methods in the analysis of drugs, bioorganic and bioactive compounds Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
15 Identification of stereochemistry in bioactive molecules Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
16 Determination of chirality in bioactive molecules Books and scientific Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
17 Term Exams Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 4 56
Out of Class Study (Preliminary Work, Practice) 14 8 112
Assesment Related Works
Homeworks, Projects, Others 2 4 8
Mid-term Exams (Written, Oral, etc.) 1 12 12
Final Exam 1 24 24
Total Workload (Hour) 212
Total Workload / 25 (h) 8,48
ECTS 8 ECTS

Update Time: 14.05.2024 04:49