TÜRKÇE
ENGLISH
Information
| Code | FİZ692 |
| Name | Experimental hypertension models |
| Term | 2000-2001 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. BESİM ÖZAYKAN |
| Course Instructor |
1 |
Course Goal / Objective
To gain the necessary theoretical and practical knowledge and skills for the creation of experimental hypertension models
Course Content
Types of clinical hypertension and the mechanisms of their formation: A) extracellular fluid-induced experimental hypertension models in rats: a) Subtotal nephrectomy-salt hypertension; b) DOCA-salt hypertension, c) One kidney- one clip salt hypertension; B) Hypertension model in rats with increased renin: two kidney- one clip (Goldblatt) hypertension; application of surgical procedures which are related to the models, measurement of hemodynamic values in animals and discussion of the mechanism of development of hypertension
Course Precondition
To have taken undergraduate human physiology course
Resources
Guyton and Hall Textbook of Medical Physiology, 14th Edition
Notes
Articles on the subject
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Counts the main features of extracellular fluid-induced hypertension models in rats |
| LO02 | Applies surgical procedures related to experimental hypertension models |
| LO03 | Measures hemodynamic values in experimental hypertension models in rodents |
| LO04 | Understands the mechanism of occurrence of subtotal nephrectomy-salt hypertension |
| LO05 | Understands the mechanism of formation of one kidney-one clip salt hypertension |
| LO06 | Comprehends the mechanism of occurrence of hypertension in two kidney-clips (Goldblatt) |
| LO07 | Interprets the similarities and differences between the mechanisms of experimental hypertension models |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The main factors that determine blood pressure | Reading the relevant part of the basic physiology book; Reading related literature | |
| 2 | System disorders caused by blood pressure abnormalities | Reading the relevant part of the pathophysiology book; Reading related literature | |
| 3 | Basic features of clinical hypertension | Reading the relevant part of the pathophysiology book; Reading related literature | |
| 4 | Basic approaches in the treatment of clinical hypertension | Reading the related part of the book on internal diseases; Reading related literature | |
| 5 | Basic characteristics of the experimental hypertension models which are the equivalences of clinical hypertension | Reading related literature | |
| 6 | Similarities and differences between clinical and experimental hypertension induced by extracellular fluid expansion | Reading related literature | |
| 7 | Mechanisms of formation of subtotal nephrectomy-salt hypertension | Reading related literature | |
| 8 | Mid-Term Exam | ||
| 9 | Application of surgical procedures for the formation of subtotal nephrectomy-salt hypertension in rats | Reading related literature | |
| 10 | Mechanisms of the formation of DOCA-salt hypertension | Reading related literature | |
| 11 | Application of surgical procedures for establishing DOCA-salt hypertension in rats | Reading related literature | |
| 12 | Mechanisms of the formation of two kidneys-one clip hypertension with high-renin | Reading related literature | |
| 13 | Application of surgical procedures for the formation of two kidneys-one clip hypertension with high-renin in rats | Reading related literature | |
| 14 | Measurement methods of hemodynamic values in hypertension models | Reading related literature | |
| 15 | Application of measurements of hemodynamic values in hypertension models | Reading related literature | |
| 16 | Term Exams | ||
| 17 | Term Exams |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 3 | 3 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 125 | ||
| Total Workload / 25 (h) | 5,00 | ||
| ECTS | 5 ECTS | ||