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Information
| Code | BİO523 |
| Name | Developmental Biology and Genetics |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. DAVUT ALPTEKİN |
| Course Instructor |
Prof. Dr. DAVUT ALPTEKİN
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Development of embryo, first differentiation in development, stem cells, genes that add to development, programmed cell death (apoptosis) is to have information about.
Course Content
General information about developmental biology and genetics. Formation of zygote, beginning of division, beginning of differentiation, morphogenesis, growth and organism formation. Stem Cells (Totipotent stem cells, Pluripotent stem cells, Multipotent stem cells). Embryonic development and factors affecting cell differentiation. The effect of nucleus. Cytoplasm content and effect of segmentation. Cell-cell effect (Hormones and Environmental Factors). Genome equivalence. Cloning. Genes that are effective in development. Double on-off systems. Maternal-acting genes in embryo formation. Zygotic genes in embryo formation. Drosophyla also segmentation model. The genes involved in this model are; Gap genes. Drosophyla also segmentation model. The genes involved in this model are; Double rule genes, Segment polarity genes. An overview of the development of Caenorhabditis elegans. Programmed cell death.
Course Precondition
None
Resources
Developmental Biologyİ. SCOTT.GILBERT, Çeviri Editörleri: Prof.Dr. Melike ERKAN, Prof.Dr. Tülay İREZ. Nobel TIP Kitabevi, 2013
Notes
Lecturer Lecture Notes and Slides
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To have general information about Developmental Biology and Genetics. |
| LO02 | Learn about the formation of the zygote, the beginning of the division, the beginning of differentiation, morphogenesis, growth and formation of organisms. |
| LO03 | Learns the basic information about Stem Cells (Totipotent stem cells, Pluripotent stem cells, Multipotent stem cells). |
| LO04 | Learns the factors affecting embryonic development and cell differentiation. |
| LO05 | Learns the effect of nucleus, cytoplasm content and segmentation on development. |
| LO06 | Have knowledge about cell-cell effect (Hormones and Environmental Factors). |
| LO07 | Learns what genome equivalence is. |
| LO08 | Learns genes that are effective in cloning and development (HOX genes). |
| LO09 | Have knowledge about double on-off system genes. |
| LO10 | Learns the effect of maternal effective genes in embryo formation. |
| LO11 | Learn the effect of zygotic genes in embryo formation. |
| LO12 | Segmentation model in Drosophyla. To have knowledge about gap genes in this model. |
| LO13 | Segmentation model in Drosophyla. Have knowledge about double rule genes and segment polarity genes in this model. |
| LO14 | Have information about the development of Caenorhabditis elegans from animal models in development. |
| LO15 | Learns programmed cell death (Apoptosis). |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To comprehend the structure and functions of cells and organelles which constitute the basic structure of life | 1 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To recognize the functions of tissue and organ systems | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | To examine the structure of genetic material | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To recognize genetic diseases and genes that cause these diseases | 1 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To learn the structure of genes | 1 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To define chromosome and gene mutations | |
| PLO07 | Bilgi - Kuramsal, Olgusal | To classify heredity forms (autosomal dominant, autosomal recessive, gender-dependent dominant and recessive inheritance models) | |
| PLO08 | Bilgi - Kuramsal, Olgusal | To use molecular and cytogenetic analysis | 1 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To be able to explain the numerical and structural anomalies of autosomal and sex chromosomes | |
| PLO10 | Bilgi - Kuramsal, Olgusal | To make DNA isolation from all kinds of tissues | |
| PLO11 | Bilgi - Kuramsal, Olgusal | To prepare PCR | |
| PLO12 | Bilgi - Kuramsal, Olgusal | To make and interpret agarose and polyacrylamide gel electrophoresis | |
| PLO13 | Bilgi - Kuramsal, Olgusal | To measure the obtained DNA on the spectrophotometer | |
| PLO14 | Bilgi - Kuramsal, Olgusal | To apply and interpret QF-PCR technique | |
| PLO15 | Bilgi - Kuramsal, Olgusal | To make cell culture from blood, amnion, chorionic villus biopsy specimens and to obtain chromosome preparation | |
| PLO16 | Bilgi - Kuramsal, Olgusal | To perform karyotype analysis of chromosome preparations and to recognize and interpret all human chromosomes | |
| PLO17 | Beceriler - Bilişsel, Uygulamalı | To interpret a scientific article and to learn how to write a paper | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | General information about Developmental Biology and Genetics. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 2 | Formation of zygote, beginning of division, beginning of differentiation, morphogenesis, growth and organism formation. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 3 | Stem Cells (Totipotent stem cells, Pluripotent stem cells, Multipotent stem cells) | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 4 | Embryonic development and factors affecting cell differentiation. The effect of nucleus. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 5 | Cytoplasm content and effect of segmentation. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 6 | Cell-cell effect (Hormones and Environmental Factors). | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 7 | Genome equivalence. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Exam question preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | The Cloning. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 10 | Genes that are effective in development. Double on-off systems. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 11 | Maternal-acting genes in embryo formation. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 12 | Zygotic genes in embryo formation. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 13 | Segmentation model in Drosophyla. The genes involved in this model are; Gap genes (Gap genes). | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 14 | Segmentation model in Drosophyla. The genes involved in this model are; Double rule genes, Segment polarity genes. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 15 | Overview of the development of Caenorhabditis elegans. Programmed cell death. | Preparation of presentation. | Öğretim Yöntemleri: Anlatım |
| 16 | Term Exams | Exam question preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Exam question preparation | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 4 | 10 | 40 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 1 | 1 |
| Final Exam | 1 | 2 | 2 |
| Total Workload (Hour) | 99 | ||
| Total Workload / 25 (h) | 3,96 | ||
| ECTS | 4 ECTS | ||