ECF421 Pharmaceutical Toxicology Laboratory

2 ECTS - 0-3 Duration (T+A)- 7. Semester- 1 National Credit

Information

Code ECF421
Name Pharmaceutical Toxicology Laboratory
Term 2022-2023 Academic Year
Semester 7. Semester
Duration (T+A) 0-3 (T-A) (17 Week)
ECTS 2 ECTS
National Credit 1 National Credit
Teaching Language Türkçe
Level Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Dr. Öğr. Üyesi Göksun DEMİREL
Course Instructor Dr. Öğr. Üyesi Göksun DEMİREL (A Group) (Ins. in Charge)
Dr. Öğr. Üyesi Göksun DEMİREL (B Group) (Ins. in Charge)


Course Goal / Objective

Basic concepts of toxicology; factors affecting toxicity; the fate of xenobiotics in the body; compares the damages caused by drugs and chemical, biological and physical agents to the biological system and the effects of these damages at the macro and molecular level, analyzes and evaluates sufficient theoretical and experimental information so that they can learn to determine harmlessness limits by making toxicological risk assessments.

Course Content

Demonstration (practical approaches in toxicology, classification of poisons according to isolation techniques; isolation techniques of poisons; collection, storage and use of samples; preparation of samples; quantitative and qualitative analysis methods of toxic substances; experimental animals); isolation of acidic and alkaline drugs that cause poisoning by extraction from biological material, identification by primary direct tests and chromatographic methods and evaluation of their toxicity, evaluation of their toxicity by spectrophotometric method.

Course Precondition

None

Resources

1.Klaassen, C.D., Watkins J.W., "Casarett & Doull?s Essential of Toxicology, The McGraw Hill Companies, 2010. 2.Ellenhorn, M.J., "Medical Toxicology", Williams & Wilkins, Maryland, 1997. 3.Hayes, A.W., "Principles and Methods of Toxicology", Taylor & Francis, Philadelphia, 2001

Notes

Demirel G., Yirun A. Toxicology Laboratory Book. Çukurova University, Faculty of Pharmacy Publication No:14.


Course Learning Outcomes

Order Course Learning Outcomes
LO01 In this course, students gain, extraction and analysis of acidic and basic drugs using analytical techniques; determination of volatile substances, metallic poisons, and food additives; DNA isolation; and in vitro cytotoxicity test will be done.
LO02 Compares basic toxicological analyzes.
LO03 Analyzes by extraction of toxic substances from biological samples.
LO04 Analyzes primary direct tests of toxic substances from biological samples.
LO05 Analyzes toxic substances from biological samples by chromatographic method.
LO06 Students run quantitative analysis of toxic substances in the biological samples by spectrophotometric method.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Have sufficient knowledge in pharmaceutical field and develop the knowledge. 4
PLO02 Bilgi - Kuramsal, Olgusal Comprehends professional knowledge with ethical responsibility through current laws and legislation.
PLO03 Beceriler - Bilişsel, Uygulamalı Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. 2
PLO04 Beceriler - Bilişsel, Uygulamalı Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. 2
PLO05 Beceriler - Bilişsel, Uygulamalı Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy,
PLO06 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. 3
PLO07 Yetkinlikler - Öğrenme Yetkinliği Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. 4
PLO08 Yetkinlikler - Öğrenme Yetkinliği Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. 4
PLO09 Yetkinlikler - İletişim ve Sosyal Yetkinlik Communicates effectively in writing and speaking.
PLO10 Yetkinlikler - İletişim ve Sosyal Yetkinlik Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language.
PLO11 Yetkinlikler - İletişim ve Sosyal Yetkinlik Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity
PLO12 Yetkinlikler - Alana Özgü Yetkinlik Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field.
PLO13 Yetkinlikler - Alana Özgü Yetkinlik Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. 2
PLO14 Yetkinlikler - Alana Özgü Yetkinlik Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. 1


Week Plan

Week Topic Preparation Methods
1 Demonstration Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım
2 Isolation of some acide and alkaline drugs from urine sample by liquid-liquid extraction and determination by thin layer chromatography (TLC) Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
3 Isolation and determinaton of some volatile substances from biological sample with microdiffusion technique Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
4 Direct determination of some metalic poisons in biological samples Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
5 Determination of food additives Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
6 Determination of salicylates from serum sample with spectrophotometric assay Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
7 Spectrophotometric determination of paracetamol in plasma Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
8 Mid-Term Exam Lesson Repetition Subject Repetition An overview Ölçme Yöntemleri:
Yazılı Sınav
9 Skin irritation test Reading the Related Section of the Textbook Öğretim Yöntemleri:
Deney / Laboratuvar, Anlatım
10 MTT analysis Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
11 In vitro cytotoxicity test I Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Gösterip Yaptırma, Deney / Laboratuvar
12 In vitro cytotoxicity test II Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Gösterip Yaptırma
13 Allkaloids I Reading the Related Section of the Textbook Öğretim Yöntemleri:
Deney / Laboratuvar
14 Alkaloids II Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Deney / Laboratuvar
15 Council of Forensic Medicine visit Reading the Related Section of the Textbook Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
16 Term Exams Lesson Repetition Subject Repetition An overview Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Lesson Repetition Subject Repetition An overview Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 1 14
Out of Class Study (Preliminary Work, Practice) 14 2 28
Assesment Related Works
Homeworks, Projects, Others 0 0 0
Mid-term Exams (Written, Oral, etc.) 1 3 3
Final Exam 1 9 9
Total Workload (Hour) 54
Total Workload / 25 (h) 2,16
ECTS 2 ECTS

Update Time: 19.11.2022 06:42