ECS404 The role of drug metabolism in drug discovery and development

2 ECTS - 2-0 Duration (T+A)- 8. Semester- 2 National Credit

Information

Code ECS404
Name The role of drug metabolism in drug discovery and development
Term 2022-2023 Academic Year
Semester 8. Semester
Duration (T+A) 2-0 (T-A) (17 Week)
ECTS 2 ECTS
National Credit 2 National Credit
Teaching Language Türkçe
Level Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Dr. Öğr. Üyesi ÖZDEN TARI
Course Instructor Dr. Öğr. Üyesi ÖZDEN TARI (A Group) (Ins. in Charge)


Course Goal / Objective

Aim of this course to understanding of the metabolism of drugs, their application in the clinical, and their importance in drug discovery.

Course Content

Drugs Metabolism (Phase 1 and 2), metabolic routes and enzymes, the principles of hard drug, soft drug, active metabolite and prodrug, the role of drug metabolism in drug development.

Course Precondition

None

Resources

H. Akgün, A. Balkan, A. A. Bilgin, Ü. Çalış ve ark. Farmasötik Kimya Kitabı, Hacettepe Üniversitesi Yayınları, 2013.

Notes

TH. Akgün, A. Balkan, A. A. Bilgin, Ü. Çalış ve ark. Farmasötik Kimya Kitabı, Hacettepe Üniversitesi Yayınları, 2013.


Course Learning Outcomes

Order Course Learning Outcomes
LO01 classifies metabolic routes and enzymes.
LO02 Explains the metabolism of drugs and its application to pharmacotherapy.
LO03 Explains the principles of hard drug, soft drug and prodrug.
LO04 Explains concepts of the active metabolite and inactive metabolite.
LO05 Explains the role of drug metabolism in drug development.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Have sufficient knowledge in pharmaceutical field and develop the knowledge. 4
PLO02 Bilgi - Kuramsal, Olgusal Comprehends professional knowledge with ethical responsibility through current laws and legislation. 1
PLO03 Beceriler - Bilişsel, Uygulamalı Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. 2
PLO04 Beceriler - Bilişsel, Uygulamalı Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. 1
PLO05 Beceriler - Bilişsel, Uygulamalı Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, 2
PLO06 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. 1
PLO07 Yetkinlikler - Öğrenme Yetkinliği Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. 3
PLO08 Yetkinlikler - Öğrenme Yetkinliği Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. 3
PLO09 Yetkinlikler - İletişim ve Sosyal Yetkinlik Communicates effectively in writing and speaking. 2
PLO10 Yetkinlikler - İletişim ve Sosyal Yetkinlik Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language.
PLO11 Yetkinlikler - İletişim ve Sosyal Yetkinlik Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity
PLO12 Yetkinlikler - Alana Özgü Yetkinlik Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field.
PLO13 Yetkinlikler - Alana Özgü Yetkinlik Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health.
PLO14 Yetkinlikler - Alana Özgü Yetkinlik Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. 3


Week Plan

Week Topic Preparation Methods
1 Drug Metabolism-Phase 1 Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
2 Drug Metabolism-Phase 2 Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
3 Hard Drug and Soft Drug Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
4 Examples of Hard Drug and Soft Drug Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
5 Active Metabolite Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
6 Examples of Active Metabolite Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
7 Prodrug Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
8 Mid-Term Exam Repetition of lecture notes Ölçme Yöntemleri:
Yazılı Sınav
9 Examples of Prodrug Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
10 CYP450 Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
11 Induction and Inhibition of CYP450 Isoforms Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
12 Polymorphism Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
13 Polymorphism-PM, EM, UM Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
14 Drug-Drug Interactions Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
15 Food-Drug Interactions Reading the relevant lecture note Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
16 Term Exams Repetition of lecture notes Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Repetition of lecture notes Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 2 28
Out of Class Study (Preliminary Work, Practice) 14 1 14
Assesment Related Works
Homeworks, Projects, Others 0 0 0
Mid-term Exams (Written, Oral, etc.) 1 4 4
Final Exam 1 8 8
Total Workload (Hour) 54
Total Workload / 25 (h) 2,16
ECTS 2 ECTS

Update Time: 14.11.2022 09:16