TÜRKÇE
ENGLISH
Information
| Code | ECS412 |
| Name | NMR Spectroscopy in Drug Determination |
| Term | 2022-2023 Academic Year |
| Semester | 8. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. Hacı Ali DÖNDAŞ |
| Course Instructor |
Prof. Dr. Hacı Ali DÖNDAŞ
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The scope of this course is to teach NMR techniques and use them to determine the structure of drug active substances and bioactive compounds.
Course Content
Basic concepts in NMR spectroscopy, Nuclear spin and resonance, The chemical shift and the factors effecting chemical shift in NMR, Solvents in the NMR, Spin-spin coupling, Using 1H-NMR and 13C-NMR spectra to determine and evaluate in the synthesis of drug molecules, 2D-COSY, APT, DEPT, HETCOR, HMQC and NOE spectroscopic techniques in the NMR. Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules
Course Precondition
None.
Resources
1.Williams H. D., Fleming I. Spectroscopic methods in organic chemistr. Fourth Edt. Revised, McGraw-Hill Book Company, England, 1989. 2. Balcı M. Nükleer manyetik rezonans Spektroskopisi ODTÜ Geliştirme Vakfı Yayıncılık ve İletişim A.Ş. Birinci Baskı, Ankara, 2000. 3. Basic one-and-two-dimensional NMR spectroscopy -Horst Friebolin, Transl. by Jack Becconsall 1993 4. Modern NMR spectroscopy: a guide for chemists -Jeremy K.M Sanders, Brian K. Hunter 1993
Notes
Lecture presentations and internet
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To know and define the basic concepts of nuclear magnetic resonance (NMR) spectroscopy. |
| LO02 | Take the 1H-NMR and 13C-NMR spectra during the synthesis of drug and bioactive molecules |
| LO03 | To evaluate the spectra for the drug molecules |
| LO04 | Determine the structure and stereochemistry of drug active substances using NMR techniques |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | 4 |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 3 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Basic concepts in NMR spectroscopy | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Nuclear spin and resonance | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Chemical shift and factors affecting chemical shift in the NMR 1 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Chemical shift and factors affecting chemical shift in the NMR 2 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Spin-spin coupling | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | The solvents and their properties used in NMR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Structural evaulation of 1H-NMR and 13C-NMR spectra during synthesis of drug molecules 1 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Subject repetition | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Structural evaulation of 1H-NMR and 13C-NMR spectra during synthesis of drug molecules 2 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | 2D-COSY, APT, DEPT spectroscopic techniques in NMR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | HETCOR, HMQC and NOE spectroscopic techniques in NMR | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | 1H-NMR and 13C-NMR spectra for the characterization of drug active component and bioactive molecules | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. 1 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. 2 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. 3 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Mid-Term Exams | Subject repetition | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Subject repetition | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||