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Information
| Code | BT567 |
| Name | Drug Development and Synthesis of Bioactive Molecules |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 8 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
1 |
Course Goal / Objective
The objective of this course, it is aimed to teach new drug development strategies, biomolecules and design and synthesis strategies of bioactive therapeutic molecules that can be drug active ingredients.
Course Content
Molecular Modeling in drug design,Stages of Drug Development,Computer Aided Drug Design (CADDs).Drug active incredients and Properties of bioactive compounds,Combinatorial chemistry,High-throughput screening(HTS) and Quantitave structurc-activity relationship (QSAR) in drug discovery.Biomolecules and biosynthesis strategies,proteins,enzymes,nucleic acids,ribopshophoramides and oligoribonucleotides.Biosensors, Development of therapeutic molecules in molecular biology,lead compounds,Synthetic methods for preparation of drug active biactive molecules,synthesis of analogues, semi-synthetic strategies,biosyntheses and full syntheses.
Course Precondition
None
Resources
Patrick, GL An Introduction to Medicinal hemistry, 5 th Ed. Oxford University Press, 2013 Beale, JM., Block, JH. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th Edition, Lippincott Williams Wilkins, 2011
Notes
Lecture notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To know and define general concepts related to drug development |
| LO02 | To know and apply the importance of molecular modeling in drug design. |
| LO03 | To know the methods used in the discovery of new drug active ingredient and molecules |
| LO04 | To gain knowledge about organic synthesis strategies |
| LO05 | To know methods of synthesis for drug active ingredient. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | 5 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 3 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | 2 |
| PLO04 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | |
| PLO06 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Knows the ethical rules to be considered while obtaining biotechnological products. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Molecular Modeling in drug design | Books an scientific database | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 2 | Drug Development Stages | Books and scientific database | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap |
| 3 | Computer Aided Drug Design (CADDs) | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Drug active molecules and properties of bioactive compounds | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | In obtaining new drug molecules; Combinatorial chemistry, Rapid scan (HTS) | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Quantitative Structure-Affect Relationships (QSAR) | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Biomolecules and biosynthesis strategies | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Proteins, enzymes, nucleic acids, ribophosphoramides and oligoribonucleotides | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 9 | Biosensors | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Development of therapeutic molecules in molecular biology | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Determination of the precursor compound | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Pharmaceutical active ingredient and bioactive molecule synthesis methods | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Synthesis of analogues and semisynthetic strategies | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Biosyntheses and full syntheses | Books and scientific database | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Biotech drugs | Books and scientific database | Öğretim Yöntemleri: Tartışma |
| 16 | Mid-term | Ölçme Yöntemleri: Yazılı Sınav |
|
| 17 | Final exam | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 8 | 112 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 4 | 8 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 212 | ||
| Total Workload / 25 (h) | 8,48 | ||
| ECTS | 8 ECTS | ||