TÜRKÇE
ENGLISH
Information
| Code | BT027 |
| Name | Metal Toxicity in Fish |
| Term | 2022-2023 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. GÜLÜZAR ATLI |
Course Goal / Objective
Role of heavy metals in aquatic ecosystem toxicity, differences between aquatic organisms in toxic flora, mechanism of uptake and excretion of metals, properties of sensitive markers in metabolic system, role of enzymatic and non-enzymatic parameters in toxic response
Course Content
Cellular responses to heavy metals at cellular level; xenobiotic metabolism, metal toxicity, mechanisms of retrieval and excretion, original detoxification organs in fish, importance of sensitive biomarkers in toxic response, characteristics of specific biomarkers, possible reactions of various organisms in acute and chronic toxic effects, DNA damage due to metal toxicity, DNA repair, Reactive oxide types, oxidative stress, antioxidant system and parameters, ozmoregulation system and Adenosine triphosphatases, various methods used as early warning system in ecotoxicology are described.
Course Precondition
None
Resources
Water pollution and fish physiology (A.G. Heath)
Notes
Articles in aquatic toxicology
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | It is informed about basic toxicity mechanisms |
| LO02 | Get information about the answers of the fish to the heavy metals at the cellular level |
| LO03 | It is informed about the xenobiotic metabolism |
| LO04 | To have information about the mechanisms of metal uptake and excretion |
| LO05 | It is informed about the importance and properties of sensitive biomarkers in toxic response |
| LO06 | It is informed about the possible reactions of various organisms against acute and chronic toxic effects |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 4 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | 5 |
| PLO04 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | |
| PLO06 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 3 |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | 5 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Knows the ethical rules to be considered while obtaining biotechnological products. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction of literature and books related to the course content | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Gösteri |
| 2 | Properties of metals, mechanisms of extraction and excretion | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 3 | Oksidative stress and reactive oxygen species | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 4 | Enzymatic mechanism parameters of antioxidant system | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 5 | Antioxidant system response in toxicity | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 6 | The role of glutathione metabolism | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 7 | The function of the AChE in the neurotoxicity of metals | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 8 | Mid-Term Exam | Preparing questions | Ölçme Yöntemleri: Ödev, Performans Değerlendirmesi |
| 9 | Metallothioneins (MT) | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 10 | The relation between MT and GSH metabolism | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 11 | The effects of environmental factors on heavy metal toxicity | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 12 | Effect of metal toxicity on osomoregulation system | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 13 | Toxic effects of metals on membrane transport systems (ATPases) | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 14 | Acute metal toxicity in aquatic organisms | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 15 | Chronic metal toxicity in aquatic organisms | The preparation of slideshow | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 16 | Term Exams | Preparing questions | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösteri |
| 17 | Term Exams | Ölçme Yöntemleri: Ödev, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 2 | 2 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 28 | 28 |
| Total Workload (Hour) | 154 | ||
| Total Workload / 25 (h) | 6,16 | ||
| ECTS | 6 ECTS | ||