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Information
| Code | FAR616 |
| Name | Toxicology |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. FATMA PEYMAN ERTUĞ |
| Course Instructor |
1 |
Course Goal / Objective
The aim of the course is to teach the toxic effects of drugs and basic concepts of toxicology, drug allergy reactions.
Course Content
Lean and special toxic effects, drug allergy, intolerance or hypersensitivity reactions, idiosyncrasy and reactions due to genetic differences, post-marketing investigation and evaluation of drug toxicity, experimental measurement of drug toxicity and therapeutic index
Course Precondition
None.
Resources
1.Medical Pharmacology in terms of Rational Treatment, Kayaalp SO, Hacettepe Taş Kitapçılık, Ankara, IX. edition, 2000 2. Goodman & Gilman's. Pharmacologic Basis of Therapeutics. Hardman JG, Limbird LE, IXth edition, McGraw-Hill, New York, 1996 Pharmacology, Rang, HP, Dale, MM, Ritter, JM, Churchill Livingstone, Edinburgh, V. edition, 2003 3.Pharmacology, Rang, HP, Dale, MM, Ritter, JM, Churchill Livingstone, Edinburgh, V. edition, 2003 4.Lippincott's Illustrated Reviews: Pharmacology, Mycek MJ, Harvey RA, Champe PC, 2nd edition, 1997
Notes
Internet, library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows the basic concepts of toxicology. |
| LO02 | Learns the toxic effects of drugs. |
| LO03 | Knows the classification of drug allergy. |
| LO04 | Gives information about the concept of teratogenicity and classification of teratogenic effect. |
| LO05 | Explain the experimental measurement of drug toxicity and therapeutic index. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Beceriler - Bilişsel, Uygulamalı | Interprets the mechanisms of action, side effects, toxic effects of drugs. | 4 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | Explain drug effects, drug interactions and effects on organ systems with a systematic approach. | 4 |
| PLO03 | Yetkinlikler - Alana Özgü Yetkinlik | Plans, implements and finalizes a scientific project | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows research areas and research techniques of pharmacology | 3 |
| PLO05 | Yetkinlikler - Alana Özgü Yetkinlik | Comparatively analysis and review scientific articles in the field of pharmacology | 3 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Prepares experimental setup and solves problems for an in vitro or in vivo pharmacological research. | 2 |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | Writes a scientific article by using data obtained from the research project. | 2 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Evaluates the use and effects of drugs in society. | 3 |
| PLO09 | Bilgi - Kuramsal, Olgusal | Explains clinical phases of drug development | 2 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Evaluates and interprets the project data statistically. | 1 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Contributes to public health with its awareness of rational drug use. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Lean Toxic Effects | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Special Toxic Effects | Reading, research | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 3 | Mutagenic (Genotoxic) Effect | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Carcinogenic (Oncogenic) effect (Chemical carcinogenesis) | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Teratogenic Effect | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Drug allergy | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Type I (anaphylactic) reactions | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Reading, revision, research | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Type II (cytotoxic) reactions | Reading, research | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 10 | Type III (due to toxic immune complex collapse) reactions | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Type IV (delayed type) reactions | Reading, research | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 12 | Intolerance or hypersensitivity reactions | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Reactions due to idiosyncrasy and genetic differences | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Post-marketing investigation and evaluation of drug toxicity | Reading, research | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 15 | Experimental measurement of drug toxicity and therapeutic index | Reading, research | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Reading, review, research | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Reading, review, research | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||