TÜRKÇE
ENGLISH
Information
| Code | Trans554 |
| Name | Cell Signaling Pathways |
| Term | 2022-2023 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
All students who take the course should acquire basic information about intercellular communication and intracellular signaling pathways, learn the biotechnological uses of this information and follow the researches on this subject.
Course Content
Definitions of receptor and signal, receptor types, intercellular messengers, intracellular signal transduction mechanisms, receptor activation and inactivation mechanisms, principles of signal cascade, oncogenic and tumor suppressor signals and mutations, methods of targeting signal pathways for therapeutic purposes in cancer, article review and presentation .
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Gain knowledge about the role of signal transduction at every stage from DNA repair to cell division, targeting methods of signal transduction pathways in the treatment of diseases and their use in the field of Translational Medicine by using interactive and research-based learning methods. |
| LO02 | In this course, students understand the mechanism of the biological behavior of cells, the receptors that affect these behaviors, the signals and how the transmission is done. |
| LO03 | Learns the evaluation of scientific articles on the related field and make article presentations |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops and deepens knowledge in the field of translational medicine to the proficiency level based on bachelor-level qualifications. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Conceives the interdisciplinary interaction in which the field is related to translational medicine | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Knows the information technologies, technical equipment, and field-specific devices and instruments at the level required by the field of Translational Medicine. | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows statistics as a tool that is constantly used in studies in the field of Translational Medicine, and uses relevant software effectively. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Uses of theoretical and practical knowledge within the field at a proficiency level. | |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Interprets the knowledge about the field by integrating the information gathered from different disciplines and formulates new knowledge. | |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Makes necessary investigations by using tools, devices, and instruments required for knowledge and technologies about translational medicine and related disciplines at an advanced level; develops a new and creative solution (device, method, treatment, drug) for the problems. | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Solves the problem faced related to the field by using research methods. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Plans and conducts an experimental study. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes responsibility and develops new strategic solutions as a team member in order to solve unexpected complex problems faced within the applications in the field, evaluates the results, and applies when necessary. | |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducts scientific studies in translational medicine and related fields independently or as a team member. | |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Publishes a scientific paper in a national journal or presents it at a scientific meeting. | |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Evaluates knowledge and skills acquired at proficiency level in the field with a critical approach and direct the learning. | |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Applies the principles of advanced professional development and lifelong learning in the field of Translational Medicine. | |
| PLO15 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates current developments and studies within the field to both professional and non-professional groups systematically using written, oral and visual techniques by supporting quantitative and qualitative data. | |
| PLO16 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates and discusses orally, in writing, and visually with peers by using a foreign language at least at a level of European Language Portfolio B2 General Level. | |
| PLO17 | Yetkinlikler - Alana Özgü Yetkinlik | Develops strategy, policy, and implementation plans on the issues related to the field and assess the findings within the frame of quality processes and ethics. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Aims and objectives of cellular signal transmission course, discussion of course content and plan, students' expectations. Definitions related to cell signaling | Öğretim Yöntemleri: Soru-Cevap |
|
| 2 | Types of intercellular communication – cytokines and peptide messengers | Öğretim Yöntemleri: Grup Çalışması |
|
| 3 | Types of intercellular communication – genomic messengers | Öğretim Yöntemleri: Grup Çalışması |
|
| 4 | Types of receptors | Öğretim Yöntemleri: Tartışma |
|
| 5 | Receptor tyrosine kinase family | Öğretim Yöntemleri: Grup Çalışması |
|
| 6 | G-protein coupled receptors | Öğretim Yöntemleri: Grup Çalışması |
|
| 7 | Intracellular signaling pathways | Öğretim Yöntemleri: Grup Çalışması |
|
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Sözlü Sınav |
|
| 9 | Receptor activation and inactivation | Öğretim Yöntemleri: Grup Çalışması |
|
| 10 | Oncogenic and tumor suppressor signals | Öğretim Yöntemleri: Grup Çalışması |
|
| 11 | Techniques to study cell signaling | Öğretim Yöntemleri: Grup Çalışması |
|
| 12 | DNA Repair System signaling | Öğretim Yöntemleri: Grup Çalışması |
|
| 13 | Epigenetics and signaling | Öğretim Yöntemleri: Grup Çalışması |
|
| 14 | Small RNAs and signaling | Öğretim Yöntemleri: Grup Çalışması |
|
| 15 | Article presentations | Öğretim Yöntemleri: Bireysel Çalışma |
|
| 16 | Term Exams | Ölçme Yöntemleri: Ödev |
|
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 12 | 12 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 114 | ||
| Total Workload / 25 (h) | 4,56 | ||
| ECTS | 5 ECTS | ||