ECS412 NMR Spectroscopy in Drug Determination

2 ECTS - 2-0 Duration (T+A)- 8. Semester- 2 National Credit

Information

Code ECS412
Name NMR Spectroscopy in Drug Determination
Term 2023-2024 Academic Year
Semester 8. Semester
Duration (T+A) 2-0 (T-A) (17 Week)
ECTS 2 ECTS
National Credit 2 National Credit
Teaching Language Türkçe
Level Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. Hacı Ali DÖNDAŞ
Course Instructor Prof. Dr. Hacı Ali DÖNDAŞ (A Group) (Ins. in Charge)


Course Goal / Objective

The scope of this course is to teach NMR techniques and use them to determine the structure of drug active substances and bioactive compounds.

Course Content

Basic concepts in NMR spectroscopy, Nuclear spin and resonance, The chemical shift and the factors effecting chemical shift in NMR, Solvents in the NMR, Spin-spin coupling, Using 1H-NMR and 13C-NMR spectra to determine and evaluate in the synthesis of drug molecules, 2D-COSY, APT, DEPT, HETCOR, HMQC and NOE spectroscopic techniques in the NMR. Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules

Course Precondition

None.

Resources

1.Williams H. D., Fleming I. Spectroscopic methods in organic chemistr. Fourth Edt. Revised, McGraw-Hill Book Company, England, 1989. 2. Balcı M. Nükleer manyetik rezonans Spektroskopisi ODTÜ Geliştirme Vakfı Yayıncılık ve İletişim A.Ş. Birinci Baskı, Ankara, 2000. 3. Basic one-and-two-dimensional NMR spectroscopy -Horst Friebolin, Transl. by Jack Becconsall 1993 4. Modern NMR spectroscopy: a guide for chemists -Jeremy K.M Sanders, Brian K. Hunter 1993

Notes

Lecture presentations and internet


Course Learning Outcomes

Order Course Learning Outcomes
LO01 To know and define the basic concepts of nuclear magnetic resonance (NMR) spectroscopy.
LO02 Take the 1H-NMR and 13C-NMR spectra during the synthesis of drug and bioactive molecules
LO03 To evaluate the spectra for the drug molecules
LO04 Determine the structure and stereochemistry of drug active substances using NMR techniques


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Have sufficient knowledge in pharmaceutical field and develop the knowledge. 5
PLO02 Bilgi - Kuramsal, Olgusal Comprehends professional knowledge with ethical responsibility through current laws and legislation.
PLO03 Beceriler - Bilişsel, Uygulamalı Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach.
PLO04 Beceriler - Bilişsel, Uygulamalı Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning.
PLO05 Beceriler - Bilişsel, Uygulamalı Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, 3
PLO06 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education.
PLO07 Yetkinlikler - Öğrenme Yetkinliği Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community.
PLO08 Yetkinlikler - Öğrenme Yetkinliği Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information.
PLO09 Yetkinlikler - İletişim ve Sosyal Yetkinlik Communicates effectively in writing and speaking. 4
PLO10 Yetkinlikler - İletişim ve Sosyal Yetkinlik Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language.
PLO11 Yetkinlikler - İletişim ve Sosyal Yetkinlik Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity
PLO12 Yetkinlikler - Alana Özgü Yetkinlik Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field.
PLO13 Yetkinlikler - Alana Özgü Yetkinlik Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. 3
PLO14 Yetkinlikler - Alana Özgü Yetkinlik Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use.


Week Plan

Week Topic Preparation Methods
1 Basic concepts in NMR spectroscopy Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
2 Nuclear spin and resonance Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
3 Chemical shift and factors affecting chemical shift in the NMR 1 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
4 Chemical shift and factors affecting chemical shift in the NMR 2 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
5 Spin-spin coupling Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
6 The solvents and their properties used in NMR Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
7 Structural evaulation of 1H-NMR and 13C-NMR spectra during synthesis of drug molecules 1 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
8 Mid-Term Exam Subject repetition Ölçme Yöntemleri:
Yazılı Sınav
9 Structural evaulation of 1H-NMR and 13C-NMR spectra during synthesis of drug molecules 2 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
10 2D-COSY, APT, DEPT spectroscopic techniques in NMR Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
11 HETCOR, HMQC and NOE spectroscopic techniques in NMR Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
12 1H-NMR and 13C-NMR spectra for the characterization of drug active component and bioactive molecules Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
13 Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. 1 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
14 Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. 2 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
15 Two-dimensional NMR spectroscopy in the characterization and stereochemistry determination of drugs and bioactive molecules. 3 Books and scientific databases Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
16 Mid-Term Exams Subject repetition Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Subject repetition Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 2 28
Out of Class Study (Preliminary Work, Practice) 14 1 14
Assesment Related Works
Homeworks, Projects, Others 0 0 0
Mid-term Exams (Written, Oral, etc.) 1 4 4
Final Exam 1 8 8
Total Workload (Hour) 54
Total Workload / 25 (h) 2,16
ECTS 2 ECTS

Update Time: 04.05.2023 12:58