TÜRKÇE
ENGLISH
Information
| Code | ECS539 |
| Name | Drug Development and Active Ingredient Synthesis Methods |
| Term | 2023-2024 Academic Year |
| Semester | 9. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. Hacı Ali DÖNDAŞ |
| Course Instructor |
Prof. Dr. Hacı Ali DÖNDAŞ
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
The scope of this course is to teach the drug development and drug active substance synthesis strategies
Course Content
Drug Development, Molecular Modeling in Drug Design, Computer Aided Drug Design (CADDs), In the development of new drug molecules; Combinatorial chemistry, High throughput screening (HTS) and Quantitative structure activity relationship (QSAR), Organic synthesis strategies, synthetic methods for drug active substance, Determination of the lead compound, Synthesis of analogues and Chemical modification, Semi synthetic strategies, biosynthesis and Full synthesis
Course Precondition
none.
Resources
1. Patrick, GL An Introduction to Medicinal Chemistry, 5 th Ed. Oxford University Press, 2013 2. Beale, JM., Block, JH. Wilson and Gisvold s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th Edition, Lippincott Williams Wilkins, 2011. 3. Roche, VF, Zito, SW Lemke, TL Williams DA Foye s Principles of Medicinal Chemistry 8th Edition, Lippincott Williams Wilkins, 2019. 4. Roberts, S.M. Ganellin, C.R, Medicinal Chemistry: the role of organic chemistry in drug research, Academic Press; 1999 5. Bugg, T. Introduction to Enzyme and Coenzyme Chemistry, Second Edition Blackwell Publishing, 2004 6. Walla, P.J, Modern Biophysical Chemistry: Detection and Analysis of Biomolecules, Expanded Ed., Wiley Blackwell , 2014. 7. A.R., Molecular Modelling: Principles and Applications, Second Ed. Prentice Hall, Pearson Education Limited, England, 2001. 8-F.JENSEN, Introduction to Computational Chemistry, John Wiley and Sons, New York, 1999 9. Molecular Modeling, Basic Principles and Applications 1997. H.-D. Höltje, W. Sippl. D. Rognan, G. Folkers. VCH, Weinheim Federal Republic of Germany.
Notes
Lecture presentations and internet
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | To define the general concepts related to molecular modeling in drug design |
| LO02 | To know the methods used in the development of new molecules |
| LO03 | To describe the information about organic synthesis strategies |
| LO04 | To know drug the synthetic methods about drug active substance |
| LO05 | To describe the importance of molecular modeling in drug desig |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 4 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | 4 |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 3 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Drug Development | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Molecular Modeling in Drug Design | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Computer Aided Drug Design (CADDs) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Combinatorial chemistry | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | High-throughput screening (HTS) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Quantitative structure activity relationship (QSAR) | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Organic synthesis strategies | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Subject repetition | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Synthetic methods for drug active substance | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Determination of the lead compound | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Synthesis of analogues and Chemical modification | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Semi-synthetic strategies | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | biosynthesis | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Full synthesis 1 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Full synthesis 2 | Books and scientific databases | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Mid-Term Exam | Subject repetition | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Subject repetition | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 78 | ||
| Total Workload / 25 (h) | 3,12 | ||
| ECTS | 3 ECTS | ||