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Information
| Code | BY734 |
| Name | Xenobiotic metabolism |
| Term | 2023-2024 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. ELİF ORUÇ |
Course Goal / Objective
The purpose of this online course is to provide an advance understanding of drug and foreign chemicals' metabolism and related methodology
Course Content
This course includes the biochemical mechanisms for the absorption, distribution and biotransformation of drugs and foreign compounds, induction mechanisms, and related scientific research methods.
Course Precondition
none
Resources
Biochemical Toxicology
Notes
Toxicology Books
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | defines toxicology, types of toxic substances, and methods of exposure. |
| LO02 | Discuss how drugs and other xenobiotics are metabolized in the body |
| LO03 | explains the tissue specific distribution of toxic substances |
| LO04 | Distinguishes Phase 1 (metabolism) and Phase 2 (conjugation) biotransformation |
| LO05 | Comprehend the role of enzyme induction and inhibition for biotransformation |
| LO06 | Understand the mode of action and side effects of chemicals as a consequence of xenobiotic metabolism. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the qualifications of the graduate, it develops and deepens the current and advanced knowledge in the field with original thought and / or research at the level of expertise and reaches the original definitions that will bring innovation to the field. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Evaluates, uses and transfers new information in the field with a systematic approach. | 5 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Develops a new idea, method, design and / or application that brings innovation to the field, or applies a known idea, method, design and / or application to a different field, researches, comprehends, designs and applies an original topic. | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Gains high level skills in using research methods in the field studies. | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Extends the boundaries of knowledge in the field by publishing at least one scientific paper in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Examines and develops the social relations and the norms that direct these relations from a critical point of view. | 4 |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Defends his / her original opinions in discussing the subjects in his / her field with experts, and establishes an effective communication showing his / her competence in his / her field. | 3 |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Introducing scientific, technological, social or cultural advances in the field; It contributes to the process of being a society of knowledge and sustaining it. | 3 |
| PLO10 | Yetkinlikler - Öğrenme Yetkinliği | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | 4 |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | definition of toxicology | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | types of toxic substances | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Types of exposure | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Tissue specific toxic effect of different toxic substances | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | disposition of toxic substances on body of animal and human | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Xenobiotic-Metabolizing Enzymes | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Phase 1 (Oxidation) Metabolism | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Phase 2 (Conjugation) Metabolism | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Excretion of Xenobiotics | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Bioactivation reactions of xenobiotics | Study the relevant methodologies and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma |
| 12 | Factors Affecting xenobiotic-Metabolizing Reactions | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Drug Transporters and Transport Mechanisms | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Pharmacogenomics I | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Pharmacogenomics II | Study the relevant methodologies and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
|
| 17 | Term Exams | Ölçme Yöntemleri: Ödev, Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 6 | 84 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 6 | 12 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 12 | 12 |
| Total Workload (Hour) | 142 | ||
| Total Workload / 25 (h) | 5,68 | ||
| ECTS | 6 ECTS | ||