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Information
| Code | BİO648 |
| Name | Immunogenetics |
| Term | 2023-2024 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
The student who completed this course; taking part in the Immunology; Antibody recognizes the properties of T Cell Receptor and MHC system, genetic mechanisms that provide diversity and importance of antigen processing and presentation. know the general information about the immune system, cells and organs, learn the mechanisms of action of natural and acquired immunity. It has information about the molecular basis for the processing of antigens entering the body and presentation to the immune system. In light of this information enables us to analyze new and complex ideas , develop up-to-date information in immunology, original thought and research and expertise.
Course Content
Introduction to immune system, history and evolution, Antigen and Tolerance concepts, Molecules and systems involved in immunology, Genetic mechanisms that provide antibody differentiation, T cell receptor differentiation and development mechanisms, MHC gene and its function, Antigen processing and presentation, Immune response genes and MHC association, Hereditary immune system diseases, important and diversty of TLR receptor, Tumor immunology, immunotherapy
Course Precondition
Gene Genome Proteome and Aging Biology and Genetics courses must be taken
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020
Notes
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows he importance of antibody, T cell receptor and MHC system with the role of immune recognition |
| LO02 | Knows the importance of genetic mechanisms that provide diversity, antigen processing and presentation |
| LO03 | Having knowledge about mechanisms of antibody formation, genetic mechanisms that provide TCR diversity. |
| LO04 | To understand MHC gene structure and its importance. |
| LO05 | To understand the relationship between MHC gene polymorphism and antigen presentation |
| LO06 | To understand general information about cells and organs of immune system. |
| LO07 | Understand the genetic link between the MHC system and autoimmunity |
| LO08 | Having knowledge about the relationship between protein processing and folding and MHC presentation. |
| LO09 | To understand the relationship between MHC system and tumor immunology |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | 4 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | 3 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | 2 |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 2 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to immune system, history and evolution | preliminary research on the subject from source books | Öğretim Yöntemleri: Tartışma, Anlatım |
| 2 | Antigen and Tolerance concepts | preliminary research on the subject from source books | Öğretim Yöntemleri: Tartışma |
| 3 | Molecules and systems involved in immunology | preliminary research on the subject from source books | Öğretim Yöntemleri: Tartışma |
| 4 | Genetic mechanisms that provide antibody differentiation | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım, Tartışma |
| 5 | T cell receptor differentiation and development mechanisms | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım, Tartışma |
| 6 | MHC gene and its function | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım |
| 7 | Antigen processing and presentation | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Evaluation-Examination | Ölçme Yöntemleri: Sözlü Sınav |
| 9 | Immune response genes and MHC associatio | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | TLR receptor diversity and its importance | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım |
| 11 | Hereditary immune system disease | preliminary research on the subject from source books | Öğretim Yöntemleri: Tartışma |
| 12 | Defense against infectious agents | preliminary research on the subject from source books | Öğretim Yöntemleri: Tartışma, Soru-Cevap |
| 13 | Immunlogic tolerance and autoimmunity | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım |
| 14 | Tumor immunology | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım |
| 15 | immunotherapy | preliminary research on the subject from source books | Öğretim Yöntemleri: Anlatım, Tartışma |
| 16 | Term Exams | Evaluation-Examination | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
| 17 | Term Exams | Evaluation-Examination | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 4 | 10 | 40 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 130 | ||
| Total Workload / 25 (h) | 5,20 | ||
| ECTS | 5 ECTS | ||