TÜRKÇE
ENGLISH
Information
| Code | ECS404 |
| Name | The role of drug metabolism in drug discovery and development |
| Term | 2024-2025 Academic Year |
| Semester | 8. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 2 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi ÖZDEN TARI |
| Course Instructor |
1 2 |
Course Goal / Objective
Aim of this course to understanding of the metabolism of drugs, their application in the clinical, and their importance in drug discovery.
Course Content
Drugs Metabolism (Phase 1 and 2), metabolic routes and enzymes, the principles of hard drug, soft drug, active metabolite and prodrug, the role of drug metabolism in drug development.
Course Precondition
None
Resources
H. Akgün, A. Balkan, A. A. Bilgin, Ü. Çalış ve ark. Farmasötik Kimya Kitabı, Hacettepe Üniversitesi Yayınları, 2013.
Notes
TH. Akgün, A. Balkan, A. A. Bilgin, Ü. Çalış ve ark. Farmasötik Kimya Kitabı, Hacettepe Üniversitesi Yayınları, 2013.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | classifies metabolic routes and enzymes. |
| LO02 | Explains the metabolism of drugs and its application to pharmacotherapy. |
| LO03 | Explains the principles of hard drug, soft drug and prodrug. |
| LO04 | Explains concepts of the active metabolite and inactive metabolite. |
| LO05 | Explains the role of drug metabolism in drug development. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | 1 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 2 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 1 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | 2 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 1 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 3 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | 3 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | 2 |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Drug Metabolism-Phase 1 | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Drug Metabolism-Phase 2 | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Hard Drug and Soft Drug | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Examples of Hard Drug and Soft Drug | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Active Metabolite | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Examples of Active Metabolite | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Prodrug | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Repetition of lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Examples of Prodrug | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | CYP450 | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Induction and Inhibition of CYP450 Isoforms | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Polymorphism | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Polymorphism-PM, EM, UM | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Drug-Drug Interactions | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Food-Drug Interactions | Reading the relevant lecture note | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Repetition of lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Repetition of lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 4 | 4 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 54 | ||
| Total Workload / 25 (h) | 2,16 | ||
| ECTS | 2 ECTS | ||