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Information
| Code | BLS403 |
| Name | Epigenetics |
| Term | 2024-2025 Academic Year |
| Semester | 7. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. ELİF ORUÇ |
| Course Instructor |
1 2 |
Course Goal / Objective
This course aims to understand the assessment of epigenetic mechanisms of gene regulation, epigenetic controls cause to human diseases and their novel therapies.
Course Content
The history of epigenetics, mechanisms of epigenetic processes, methods used and model organism studies, epigenetic-related human diseases, epigenome and epigenetic therapy constitute the content of this course.
Course Precondition
None
Resources
Epigenetics (2015) : C. David Allis and Manika Lancher, Cold Spring Harbor, NY, 984 p.
Notes
Epigenetics in Biolgy and Medicine (2009), Manel Esteller, CRC Press, Taylor and Francis Group, LLC, 316 p.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explains epigenetic mechanisms |
| LO02 | Explaines the relationship between epigenetics and human diseases. |
| LO03 | Evaluates and Discuss the methodologies in epigenetics field |
| LO04 | Explains epigenetic treatment methods |
| LO05 | Explains model organisms used in epigenetic studies and methods |
| LO06 | Explaines the impact of environmental agents and diet on the epigenome |
| LO07 | Understands the relationship between epigenetics and cancer formation mechanisms |
| LO08 | Have knowledge about stem cells and Epigenetic treatment methods |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the basic concepts and principles in biology | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | The knowledge gained in the field of biology combine with information from other sciences. | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Identifies problems in the field of biology and apply methods for their solution | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Describes the method of producing scientific knowledge in the field of biology | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | They will receive information on the biology area, in order to classify it uses and purposes. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | They use advanced theoretical and practical knowledge that obtain in biology field. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | They are Field-related issues can inform the relevant persons and institutions, They share ideas and problems relating to suggestions as the written, oral and Visual to expert or transfer to non-experts. | |
| PLO08 | Bilgi - Kuramsal, Olgusal | They can take responsibility as individuals and team members to solve unpredictable problems encountered in applications related to the field. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | they can take an active role as a member of the execution team the planning of projects related to the field. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | They know that life-long learning process and act accordingly. | 4 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | They will increase the knowledge and experience outside major issues with specific elective courses in different fields of biology. | |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | They speak English enough to communicate with colleagues to understand the basic concepts of biology. | |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | They both with colleagues, as well as areas with non-person establishes ethical uses of information and communication technology. In addition to professional development, in line with the interests and abilities of scientific, social, constantly improves itself by identifying learning needs in cultural and artistic fields. | |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | They assesses developments in biology versatile using scientific methods and techniques | |
| PLO15 | Yetkinlikler - Öğrenme Yetkinliği | They know the importance of personal development and enforces the need. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | History of epigenetics, Why we need epigenetics | Lecture Notes, Literature browsing and reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Epigenetic mechanisms: DNA Methylation | Lecture Notes Literature browsing and reading | Öğretim Yöntemleri: Anlatım, Tartışma |
| 3 | Epigenetic mechanisms: Histone Modification | Lecture Notes, Literature browsing and reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Epigenetic technology: DNA methylation analysis | Lecture Notes, Literature browsing and reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Epigenetic technology: Chromosome immunoprecipitation | Lecture Notes, Literature browsing and reading | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Model organisms used in epigenetic studies | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Metabolism and epigenetics | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Literature browsing and reading Lecture notes | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Stem cell and cellular differentiation, X chromosome inactivation, genomic imprinting | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Diet, impact of environmental agents on the epigenome, population pharmacoepigenomics | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Cancer epigenetics | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Epigenetics and immunity | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Epigenetics and epigenomics | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Epigenetic therapy | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 15 | Epigenetics and epidemiology | Lecture Notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Lecture notes | Ölçme Yöntemleri: Yazılı Sınav, Ödev, Proje / Tasarım |
| 17 | Term Exams | Lecture notes | Ölçme Yöntemleri: Ödev, Proje / Tasarım, Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 4 | 8 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 15 | 15 |
| Total Workload (Hour) | 94 | ||
| Total Workload / 25 (h) | 3,76 | ||
| ECTS | 4 ECTS | ||