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Information
| Code | BL494 |
| Name | Toxicology |
| Term | 2024-2025 Academic Year |
| Semester | 8. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. ELİF ORUÇ |
| Course Instructor |
1 2 |
Course Goal / Objective
The aim of this course is to provıde knowledge and understanding about the principles of toxicology, xenobiotic metabolism. Also it will be discussed on cell damage together with biochemical and molecular toxicity mechanisms of xenobiotics.
Course Content
This course includes; Principles of toxicology, toxic effect mechanisms of xenobiotics, cell damage and protective mechanisms
Course Precondition
None
Resources
Casarett and Doull's Principles of Toxicology
Notes
Toxicology (Nevin Yıldırım, Ankara University)
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Understands the general principles of toxicology, absorption, distribution, metabolism, side of action and excretion of toxic substance |
| LO02 | Explains toxic effect mechanisms of xenobiotics |
| LO03 | have detail information about cell damage and protective mechanisms |
| LO04 | classified the detail information about hepatotoxicity |
| LO05 | have detail information about neurotoxicity |
| LO06 | Explain hydroxylation reactions |
| LO07 | Explain Phase II Conjugation reactions |
| LO08 | Explain kidney toxicity |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the basic concepts and principles in biology | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | The knowledge gained in the field of biology combine with information from other sciences. | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Identifies problems in the field of biology and apply methods for their solution | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Describes the method of producing scientific knowledge in the field of biology | |
| PLO05 | Bilgi - Kuramsal, Olgusal | They will receive information on the biology area, in order to classify it uses and purposes. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | They use advanced theoretical and practical knowledge that obtain in biology field. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | They are Field-related issues can inform the relevant persons and institutions, They share ideas and problems relating to suggestions as the written, oral and Visual to expert or transfer to non-experts. | 3 |
| PLO08 | Bilgi - Kuramsal, Olgusal | They can take responsibility as individuals and team members to solve unpredictable problems encountered in applications related to the field. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | they can take an active role as a member of the execution team the planning of projects related to the field. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | They know that life-long learning process and act accordingly. | 4 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | They will increase the knowledge and experience outside major issues with specific elective courses in different fields of biology. | |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | They speak English enough to communicate with colleagues to understand the basic concepts of biology. | |
| PLO13 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | They both with colleagues, as well as areas with non-person establishes ethical uses of information and communication technology. In addition to professional development, in line with the interests and abilities of scientific, social, constantly improves itself by identifying learning needs in cultural and artistic fields. | 4 |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | They assesses developments in biology versatile using scientific methods and techniques | 3 |
| PLO15 | Yetkinlikler - Öğrenme Yetkinliği | They know the importance of personal development and enforces the need. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to toxicology | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Tartışma |
| 2 | Absorption, distribution, metabolism, side of action and excretion | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Phase I metabolism and pharmacogenetic | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması |
| 4 | Conjugation and elimination of toxic substances | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Physiological factors affecting xenobiotic metabolism | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Adaptation | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Cell injury and cellular protection mechanism | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Review of the relevant pages from sources | Ölçme Yöntemleri: Yazılı Sınav, Proje / Tasarım, Performans Değerlendirmesi |
| 9 | Reactive metabolites and toxicity | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Central nervous system and toxicity | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Neurodegenerative disease neurotoxicity mechanisms | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması |
| 12 | Hepatotoxicity | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması |
| 13 | Nutritional Factors | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması |
| 14 | Toxic effects of global warming | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Proje Temelli Öğrenme |
| 15 | Molecular techniques in toxicology | Review of the relevant pages from sources | Öğretim Yöntemleri: Anlatım |
| 16 | Term Exams | Ölçme Yöntemleri: Performans Değerlendirmesi, Proje / Tasarım, Yazılı Sınav |
|
| 17 | Term Exams | Ölçme Yöntemleri: Yazılı Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 88 | ||
| Total Workload / 25 (h) | 3,52 | ||
| ECTS | 4 ECTS | ||