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Information
| Code | BY054 |
| Name | Molecular Toxicology |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. ELİF ORUÇ |
| Course Instructor |
1 |
Course Goal / Objective
The aim of this course is to explain the molecular mechanisms and methodology of diseases related to cancer, neurodegenerative diseases, reproductive health and endocrine disruption caused by drugs, carcinogens and other pollutants. In addition, it is aimed to raise awareness in the field of environment and human health and to develop a strategy on sustainable living and the use of natural resources.
Course Content
This course includes the molecular mechanisms of diseases related to cancer, neurodegenerative diseases, reproductive health and endocrine disruption caused by drugs, carcinogens and pollutants at every stage of the development of the organism, their effects on genes, enzymes, receptors, hormones, as well as research methods on cell damage and protection mechanisms.
Course Precondition
None
Resources
Toxicology Books
Notes
PubMed, WOS
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Toxicology describes toxic substances and exposure to these substances |
| LO02 | Explains tissue-specific distribution of toxic substances |
| LO03 | Discusses how drugs and other xenobiotics are metabolized in the body |
| LO04 | Explains the effects caused by carcinogens and other pollutants at the molecular level |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the qualifications of the graduate, it develops and deepens the current and advanced knowledge in the field with original thought and / or research at the level of expertise and reaches the original definitions that will bring innovation to the field. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Evaluates, uses and transfers new information in the field with a systematic approach. | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Develops a new idea, method, design and / or application that brings innovation to the field, or applies a known idea, method, design and / or application to a different field, researches, comprehends, designs and applies an original topic. | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Gains high level skills in using research methods in the field studies. | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Extends the boundaries of knowledge in the field by publishing at least one scientific paper in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Examines and develops the social relations and the norms that direct these relations from a critical point of view. | |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Defends his / her original opinions in discussing the subjects in his / her field with experts, and establishes an effective communication showing his / her competence in his / her field. | 3 |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Introducing scientific, technological, social or cultural advances in the field; It contributes to the process of being a society of knowledge and sustaining it. | 3 |
| PLO10 | Yetkinlikler - Öğrenme Yetkinliği | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction: General principles of toxicology | Introduction: General principles of toxicology | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Environmental pollution, ways of entry of toxic compounds into living things, distribution | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Metabolism of toxic compounds, Phase I reactions | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Phase II Reactions | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Elimination and bioactivation of toxic compounds | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Factors affecting xenobiotic metabolism | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Adaptation to toxic substances | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
|
| 9 | Reactive oxygen species | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Mechanisms of cell damage | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Molecular techniques used in toxicology | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Drug carriers and transport mechanisms | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Toxicology and DNA | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Toxicology and RNA Expression | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Risk assessment, Exposure and Biomarker | Study of relevant methodology and resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
|
| 17 | Term Exams | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 30 | 60 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 1 | 1 |
| Final Exam | 1 | 1 | 1 |
| Total Workload (Hour) | 146 | ||
| Total Workload / 25 (h) | 5,84 | ||
| ECTS | 6 ECTS | ||