TÜRKÇE
ENGLISH
Information
| Code | VTS319 |
| Name | Stem Cells and Cellular Therapies in Veterinary Medicine |
| Term | 2024-2025 Academic Year |
| Semester | 5. Semester |
| Duration (T+A) | 1-0 (T-A) (17 Week) |
| ECTS | 1 ECTS |
| National Credit | 1 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Label | FE Field Education Courses E Elective |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Dr. Öğr. Üyesi SİNAN KANDIR |
| Course Instructor |
Dr. Öğr. Üyesi SİNAN KANDIR
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
This course aims to introduce students to stem cell biology and cellular therapy methods in veterinary medicine, raising awareness of clinical applications and ethical aspects in this field. The course covers the biological properties of stem cells, methods of obtaining them, genetic modification technologies, laboratory techniques, and cellular therapy approaches used in veterinary medicine.
Course Content
This course comprehensively covers the biology and classification of stem cells, the characteristics of embryonic and adult stem cells, the applications of mesenchymal stem cells in veterinary medicine, stem cell isolation and characterization, genetic modification techniques and gene therapies, cellular therapy protocols and clinical applications, bioreactors and laboratory cultivation of stem cells, and ethical and legal regulations in cellular therapies, providing an in-depth understanding of stem cell and cellular therapy methods in veterinary medicine.
Course Precondition
N/A
Resources
- Lecture Nores (Kandır S., 2022) - Stem Cells and Signaling Pathways, Academic Press, Elsevier, 2023 - Smyth Templeton, N. (Ed.). (2015). Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition (4th ed.). CRC Press. https://doi.org/10.1201/b18002 - Somatik ve Kök Hücre Kültür Sistemlerinin Temel İlkeleri, Prof. Dr. Adil M. Allahverdiyev, Nobel Tıp Yayınevi (2018).
Notes
Related literature, lecture notes, presentations and video images related to the subject.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explains the biology and classification of stem cells. |
| LO02 | Identifies the characteristics and applications of embryonic and adult stem cells. |
| LO03 | Evaluates the use of mesenchymal stem cells in veterinary medicine. |
| LO04 | Learns the methods of stem cell isolation and characterization. |
| LO05 | Explains genetic modification techniques and gene therapies. |
| LO06 | Analyzes cellular therapy protocols and clinical applications. |
| LO07 | Explains the importance of bioreactors and laboratory cultivation of stem cells. |
| LO08 | Discusses ethical and legal regulations in cellular therapies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Distinguishes animal species and breeds based on their structural (morphological), functional (physiological, biochemical) and behavioral characteristics and whether they can be consumed for food purposes. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Explains the sources, physical and chemical properties and preparation of drugs. | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Describes the effects and side effects of medications on patients | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Explains the formation mechanisms of animal diseases and their pathological effects on the body. | |
| PLO05 | Bilgi - Kuramsal, Olgusal | It makes efficiency evaluations among animal breeds and, when necessary, carries out selection, hybridization and artificial insemination at a level that can carry out breeding work. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Disposes of dead animal material, tissue samples, medical and chemical waste appropriately in accordance with international, national laws and regulations. | |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | It determines the correct approach area for the patient by evaluating the examination, operation etc. practices in the clinic according to the topographic anatomy. | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Uses biochemical parameters in diagnostic processes by evaluating the information obtained with cause-effect relationships. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Writes prescriptions in accordance with diagnosis and treatment protocols for diseases and poisoning in animals. | 5 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Implements necessary measures, including biosecurity, to control infectious diseases. | |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Performs necropsy to evaluate findings in dead animals, directs tissues to the necessary laboratory according to appropriate storage methods and prepares a report. | |
| PLO12 | Beceriler - Bilişsel, Uygulamalı | Monitors patients in the post-operative process according to the main treatment methods of surgical diseases in animal species. | |
| PLO13 | Beceriler - Bilişsel, Uygulamalı | Applies sedation, anesthesia and pain management methods safely according to animal species. | |
| PLO14 | Beceriler - Bilişsel, Uygulamalı | Correctly applies biosafety principles such as sterilization of clinical and laboratory equipment and clothing. | |
| PLO15 | Beceriler - Bilişsel, Uygulamalı | It regulates the care and feeding protocols according to animal species and supervises the consumption of animal foods produced for human consumption or foods containing animal products in their composition. | |
| PLO16 | Beceriler - Bilişsel, Uygulamalı | Evaluates laboratory results of animal diseases and applies correct diagnosis, prognosis and treatment methods based on the data obtained. | 3 |
| PLO17 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | He/she is conscious of performing his/her profession by being aware of his/her powers and responsibilities. | |
| PLO18 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Examines scientific techniques and methods according to facts related to veterinary services and takes analysis or methodological responsibility for problems. | 4 |
| PLO19 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It uses adequate technology in the hygienic production, manufacturing, processing, consumption and sales of food by conducting health control of animal food products produced for human consumption. | |
| PLO20 | Yetkinlikler - Öğrenme Yetkinliği | Lists the methods of producing and using scientific knowledge in his/her professional field. | 4 |
| PLO21 | Yetkinlikler - Öğrenme Yetkinliği | Uses updated legislation regarding veterinary services when necessary. | 3 |
| PLO22 | Yetkinlikler - Öğrenme Yetkinliği | Performs an examination appropriate to the case, applying the contribution of imaging methods to diagnosis and radiation safety in accordance with current regulations. | |
| PLO23 | Yetkinlikler - Öğrenme Yetkinliği | Keeps clinical and patient records using proper and scientific methods. | |
| PLO24 | Yetkinlikler - Öğrenme Yetkinliği | By observing the basic principles of medicine, it develops management methods and appropriate management plans for animal production enterprises. | |
| PLO25 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Implement social projects and plans with social awareness, based on professional skills and authority with a computer usage license, advanced computer software. | |
| PLO26 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Works in cooperation with other colleagues by following the world agenda within the framework of professional ethics and deontology rules. | 4 |
| PLO27 | Yetkinlikler - Alana Özgü Yetkinlik | Produces solutions to field-specific problems in line with scientific data/evidence. | 5 |
| PLO28 | Yetkinlikler - Alana Özgü Yetkinlik | He/she has the ethical values of the veterinary profession and defends these values. | |
| PLO29 | Yetkinlikler - Alana Özgü Yetkinlik | Takes appropriate precautions by clinically recognizing zoonosis and notifiable diseases. | |
| PLO30 | Yetkinlikler - Alana Özgü Yetkinlik | Determines the methods of diagnosis, prevention, treatment and operation of diseases in different animal species. | |
| PLO31 | Yetkinlikler - Alana Özgü Yetkinlik | In emergency cases, intervenes in all animals and applies first aid methods. | |
| PLO32 | Yetkinlikler - Alana Özgü Yetkinlik | Makes judgments on animal husbandry principles and breeding by assessing the physical condition, welfare and rearing conditions of domestic animals, communicating appropriately with animal owners and colleagues. | |
| PLO33 | Yetkinlikler - Alana Özgü Yetkinlik | Independently interprets articles and presentations published in other scientific fields related to Veterinary Medicine to maintain professional development and skills. | 4 |
| PLO34 | Yetkinlikler - Alana Özgü Yetkinlik | When necessary, euthanizes animals using appropriate methods and respecting the feelings of animal owners. | |
| PLO35 | Yetkinlikler - Alana Özgü Yetkinlik | By mastering the concepts of occupational safety in terms of the workplace and the personnel working with it, they have the competence to apply and defend it. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Scope, Objectives, and Classification of Stem Cells, Types of Stem Cells, Classification Based on Differential Potentials | Basic reading on stem cell biology and classification | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Embryonic Stem Cells - Definition and Applications | Literature review on characteristics and applications of embryonic stem cells | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Örnek Olay |
| 3 | Regulation of Stem Cell Function, Hematopoietic Stem Cell Identification and Applications | Literature review on biological functions of hematopoietic stem cells | Öğretim Yöntemleri: Anlatım, Tartışma, Beyin Fırtınası, Örnek Olay |
| 4 | Mesenchymal Stem Cells, Molecular Targets for Characterization, and Applications | Review of articles on characterization and applications of mesenchymal stem cells | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Proje Temelli Öğrenme |
| 5 | Basic Cell Culture -Stem Cell Isolation and Characterization | Gaining theoretical knowledge about cell culture and cellular characterization techniques | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Gösterip Yaptırma |
| 6 | Cellular Therapy Protocols and Clinical Applications | Review of relevant literature and protocols on current cellular therapy methods | Öğretim Yöntemleri: Anlatım, Gösterip Yaptırma, Soru-Cevap, Tartışma, Grup Çalışması |
| 7 | Ethical and deontological principles in cellular therapy procedures | Review of current legal regulations in the field of use of cellular therapies in health sciences | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme |
| 8 | Mid-Term Exam | Reviewing previous topics | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev, Proje / Tasarım, Performans Değerlendirmesi |
| 9 | Gene Engineering and Recombinant DNA technology | Basic reading on genetic engineering and recombinant DNA technologies | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası, Proje Temelli Öğrenme |
| 10 | Vectors for gene cloning; plasmids and bacteriophages | Reviewing scientific articles on gene cloning vectors | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme |
| 11 | Gene cloning; examine genetic locality, structure, expression level | Literature review on gene cloning processes and gene expression levels | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme |
| 12 | Transcriptomics and proteomics analysis | Reviewing articles on transcriptomics and proteomics analyses | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme |
| 13 | Genetic diseases and current gene therapy options in pets | Reading current research on diagnosis of genetic diseases and gene therapy methods in domestic animals within the framework of literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Beyin Fırtınası, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme , Grup Çalışması |
| 14 | Genetic diseases and current gene therapy options in farm animals | Reading current research on diagnosis of genetic diseases and gene therapy methods in livestock animals within the framework of literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme |
| 15 | Bioreactors and transgenic animal technology | Literature review on bioreactor usage and transgenic animal production | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Grup Çalışması, Beyin Fırtınası, Örnek Olay, Proje Temelli Öğrenme |
| 16 | Term Exams | Reviewing previous course topics | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev, Performans Değerlendirmesi, Proje / Tasarım |
| 17 | Term Exams | Reviewing previous course topics | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev, Proje / Tasarım, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 1 | 14 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 2 | 2 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 2 | 2 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 35 | ||
| Total Workload / 25 (h) | 1,40 | ||
| ECTS | 1 ECTS | ||