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Information
| Code | BMM0086 |
| Name | Biochemical Calculations |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
The aim of this course is to understand the properties and behavior of biological molecules using basic mathematics.
Course Content
Solutions of numerical problems in biochemistry involving acid-base chemistry, blood buffers, chemistry of biological molecules, enzymes, biochemical energetics, spectrophotometry.
Course Precondition
None
Resources
Lawrence A. Kaplan, Amadeo J. Pesce Teory Analysis Correlations Clinical Chemistry. Mosby ELSEVIER, Indiana, 2010.
Notes
Carl A. Burtis, Edward R. Ashwood. Tietz Klinik kimyada temel ilkeler. Çeviri editörü Prof Dr Diler Aslan Palme yayıncılık, Ankara, 2005. 2. K. Moorthy, Fundamentals of Biochemical Calculations. 2nd Edn. CRC Press, Taylor & Francis Group, Boca Raton, FL. 2008.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Understands the properties of solutions. |
| LO02 | Learns the dissolution phenomenon and the factors affecting solubility. |
| LO03 | Have information about concentration units. |
| LO04 | Understands the calculation of ion concentrations in solution by understanding the equilibrium constant. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To be able to solve scientific problems encountered in the field of medicine and medical technologies by applying current and advanced technical approaches of mathematics, science and engineering sciences. | 3 |
| PLO02 | Yetkinlikler - Öğrenme Yetkinliği | To have a knowledge of the literature related to a sub-discipline of biomedical engineering, to define and model current problems. | 4 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Ability to analyze data, design and conduct experiments, and interpret results | 4 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Developing researched contemporary techniques and computational tools for engineering applications | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | To be able to analyze and design a process in line with a defined target | 4 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducting scientific studies with a medical doctor from an engineering perspective. | 4 |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Expressing own findings orally and in writing, clearly and concisely. | |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | To be able to improve oneself by embracing the importance of lifelong learning and by following the developments in science-technology and contemporary issues. | |
| PLO09 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Ability to act independently, set priorities and creativity. | 3 |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Being aware of national and international contemporary scientific and social problems in the field of Biomedical Engineering. | |
| PLO11 | Yetkinlikler - Alana Özgü Yetkinlik | To be able to evaluate the contribution of engineering solutions to problems in medicine, medical technologies and health in a global and social context. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Dissolution-Resolution: Dissolution of ionic and covalent (polar-nonpolar) particules | Read about the subject | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 2 | Factors affecting the resolution; temperature, pressure, solvent type. Exothermic and endothermic dissolution. | Read about the subject | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 3 | Concentration Units1: % concentrations and osmolarity Molarite-osmolality, molality-osmolality; isotonic, hypotonic and hypertonic solutions. | Read about the subject. | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Grup Çalışması |
| 4 | Concentration Units 2: Normality, equivalent grams and ionic strength calculations | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 5 | Chemical reactions and equilibrium, equilibrium of constant and rates of reaction | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 6 | Acids and Bases: Definition of Acid-base, strong and weak acids and bases; chemical properties of the acid and base | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 7 | Buffers | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 8 | Mid-Term Exam | Subject repetition and explanation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 9 | Dilutions | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 10 | Ionization of water: Kd and Ks of Water, calculation of H+ and OH- ion concentration of water | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 11 | The calculation of H + and OH- concentration in strong and weak acid-base , degree of ionization. | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 12 | pH and pOH: pH and pOH value of water; pH scale (criteria), calculation of pH and pOH related to strong-weak acid and base | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 13 | Neutralization Reactions: pH and pOH calculations in acid-base mixture, titration curves | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 14 | Amino acids of the ionization, calculations of isoelectric spot | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 15 | Hydrolysis and salts: the relationship between Ka and Kb constants for weak acids and bases | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması |
| 16 | Term Exams | Subject repetition and explanation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 17 | Term Exams | Subject repetition and explanation | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 5 | 5 | 25 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 2 | 2 |
| Final Exam | 1 | 2 | 2 |
| Total Workload (Hour) | 141 | ||
| Total Workload / 25 (h) | 5,64 | ||
| ECTS | 6 ECTS | ||