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Information
| Code | BT023 |
| Name | Biochemical Toxicology in Model Organisms |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. PETEK PİNER BENLİ |
Course Goal / Objective
The aim of this course is to teach students acute and chronic toxicity test in model animals, metabolism of toxic substences, effects of toxic substencens on biochemical processes, the biochemical and molecular markers used in toxicological studies, teratogenesis, genotoxicity and carcinogenesis, biochemical and molecular markers used in toxicity studies
Course Content
Introduction to biochemical toxicology in model animals, Dose-response relationships, Absorption, distribution, metabolism and excretion of toxic compounds, Factors affecting metabolism toxic compunds, Toxic response to foreign compounds, Teratogenesis, Genotoxicity and chemical carcinogenesis, Hepatotoxicity, Kidney damage, Lung damage, Neurotoxicity. Biochemical and molecular markers in toxicity Toxicogenomics, toxicoproteomics, toxicometabolomics
Course Precondition
None
Resources
Principles of Biochemical Toxicology Jhon A Timbrel 2008 M
Notes
olecular and Biochemical Toxicology Robert C. Smart Ernest Hodgson 2018
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Explain the dose-response relationship in toxic compounds, the absorption and distribution of toxic compounds, and their excretion. |
| LO02 | Explain metabolism of toxic compounds; Phase 1-2 Biotransformation Reactions. |
| LO03 | List the factors affecting the metabolism of toxic compounds. |
| LO04 | Explains biochemical responses to toxic compounds in their own words. |
| LO05 | Explain model organisms used in biochemical toxicology research and related studies with examples. |
| LO06 | Designs acute and chronic toxicity test designs in biochemical toxicology research. |
| LO07 | Explains the molecular and biochemical basis of teratogenic, carcinogenic and mutagenic effects of toxic compounds in model organisms with their own words. |
| LO08 | Express the biochemical and molecular markers and methods used in toxicity studies. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | 2 |
| PLO02 | Beceriler - Bilişsel, Uygulamalı | To identifiy the interdisciplinary interaction of the field and to solve use of the methods. | 1 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Interpret the knowledge gained in the field by integrating the information from different disciplines and creates new information | |
| PLO04 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new strategic approaches for solving complex problems that are encountered in applications related to the field. | |
| PLO05 | Yetkinlikler - Öğrenme Yetkinliği | To teach the social, scientific, cultural and ethical values during the collection, interpretation, implementation and announcement of the data related to the field. | 2 |
| PLO06 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | To solve the problems encountered in the field and cominicate by using research methods. | 3 |
| PLO07 | Yetkinlikler - Alana Özgü Yetkinlik | To gain the ability to develop and deepen the knowledge in the field of biotechnology | 3 |
| PLO08 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision-making processes in solving the problems encountered in the field. | |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Knows the ethical rules to be considered while obtaining biotechnological products. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to biochemical toxicology in model organisims | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım |
| 2 | Dose- response relationship, Measurement of dose-response relationships | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Absorption and distibution of toxic compounds | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Metabolism of toxic compounds: Phase-1 Biotransformation Reactions | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Metabolism of toxic compounds: Phase-2 Biotransformation Reactions | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Excretion of toxic compunds | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Factors affecting metabolism toxic compunds; Chemical factors, Biological factors | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Checkover of lecture notes | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 9 | Biochemical response toxic compounds | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 10 | Aquatic animal model for biochemical toxicity tests | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Mammalian model for biochemical toxicity tests | Checkover of lecture notes | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Gösteri |
| 12 | Teratogenic, carcinogenic, mutagenic effects of tocix coumpounds | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Hepatotoxicty, Neurotoxicity | Checkover of lecture notes | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Anlatım |
| 14 | Biochemical and molecular marker used in toxicological research | Checkover of lecture notes | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 15 | Toxicogenomics, toxicoproteomics, toxicometabolomics | Checkover of lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 16 | Term Exams | Checkover of lecture notes | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 17 | Term Exams | Checkover of lecture notes | Ölçme Yöntemleri: Ödev, Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||