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Information
| Code | BFZ552 |
| Name | Muscle Biophysics: From molecule to cell |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. AYKUT PELİT |
Course Goal / Objective
Mechanical properties of the muscles; Fenn effect, using chemical energy, heat and work, shortening and lengthening, isotonic and isometric contractions, cross bridges of myosin and actin, sliding filaments of the muscles, relations of the force-velocity and ATP kinetics.
Course Content
Skeletal muscles, Contractile forces, EMG
Course Precondition
There is no prerequisite for the lesson
Resources
Lecture notes (For Medical Faculty Students - İsmail Günay) Biophysics (Ferit Pehlivan) Biophysics (Gürbüz Çelebi) Internet Search
Notes
Internet Research
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Doing a muscle dissection independently. |
| LO02 | Learning a mechanisms of the skeletal muscles. |
| LO03 | Researching and making experiment of the skeletal muscles. |
| LO04 | The information learned systematic to mass transfer |
| LO05 | Interpretation of findings and conclusions |
| LO06 | To establish experimental setup in the lab and can work about this matter. |
| LO07 | Make a plan for experimental research in skeletal muscles. |
| LO08 | To learn general and specific information on the skeletal muscles. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Learns basic information about the field | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Sets up and works experimental setups in the laboratory | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Prepares a project proposal on its own | 1 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Plans an experimental study | |
| PLO05 | Bilgi - Kuramsal, Olgusal | Reports the research result | 1 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Interpret the research findings | 2 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Has the analytical thinking mechanism related to the field, Reaches reliable information. Creates and writes a research project, works and researches based on ethical values. | |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | She/he systematically transfers the theoretical knowledge she has researched to the audience. | 2 |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Have a scientific thinking systematic in relation to their profession. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Striated Muscles: From Molecules to Cells | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 2 | Energy Economy in the Actomyosin Interaction, Cross bridge movement, ATP hydrolysis | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 3 | Thick flaments and signifigance of the titin molecule, Contractile Characteristics of Sarcomeres, Fenn effect | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 4 | Mechanic isolation the skeletal muscles, muscle dissection | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 5 | Contractile force measurements systems | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 6 | Converters and software systems | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 7 | Force-Length relation in the sarcomeres, Tropomyosin-Troponin interactions | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 8 | Mid-Term Exam | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Performans Değerlendirmesi |
| 9 | Crossbridge and Non-crossbridge Contributions to Force in Shortening and Lengthening Muscle and Hill equation | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 10 | Effects of temperature on the cross bridge. Mechanism of the muscle weakness. | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 11 | Isometric and isotonic contractiles, fast and slow twitch muscles | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 12 | Diabetic effetcs on the skeletal muscle | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 13 | EMG Methods and electrode types | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 14 | Skin surface electromyography and Integrated EMG. | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 15 | Data Analysis, drawing curves and discussion results. | Reference Books | Öğretim Yöntemleri: Anlatım, Gösteri |
| 16 | Term Exams-1 | Term Exams-1 | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams-2 | Term Exams-2 | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 3 | 3 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 125 | ||
| Total Workload / 25 (h) | 5,00 | ||
| ECTS | 5 ECTS | ||