TÜRKÇE
ENGLISH
Information
| Code | EFR506 |
| Name | |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
1 |
Course Goal / Objective
At the end of this course, it is aimed to enable students to comprehend and interpret the basic principles of investigating signal pathways and mechanisms that determine the contractility of smooth muscle tone.
Course Content
It contains information about receptor types, signal transduction systems and pathways that play a role in the regulation of tone of smooth muscle preparations. Experimental responses of vascular, gastrointestinal and urogenital smooth muscles will be demonstrated in practice.
Course Precondition
None
Resources
Animal models in pharmacology and toxicology. In: Handbook of laboratory animal science. 2nd edition, CRC Press, 2003
Notes
pubmed
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Describe the signal pathways in the smooth muscle. |
| LO02 | Explain the mechanism of smooth muscle contraction. |
| LO03 | Explain the mechanisms of vascular smooth muscle contraction. |
| LO04 | Explain the importance of endothelium-dependent vasodilation and related mechanisms. |
| LO05 | Comprehends the contraction and relaxation functions of gastrointestinal system smooth muscles and the mechanisms mediating this function. |
| LO06 | Defines the contraction and relaxation functions of the smooth muscles of the urogenital system and the mechanisms that mediate this function. |
| LO07 | Autonomic innervation of the bladder describes drugs whose dysfunction affects bladder smooth muscle tone. |
| LO08 | The regulation of corpus cavernosum smooth muscle explains the mechanism of erectile dysfunction and drugs used in the treatment of erectile dysfunction. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 4 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | 4 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | 3 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Establishes a relationship between the effects, mechanisms of action and drug interactions of drugs. | |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | 5 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | 4 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Regulation of smooth muscle | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 2 | Receptors in the regulation of smooth muscle tone | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Vascular smooth muscle preparation: Isolated thoracic aorta | Review Literature | Öğretim Yöntemleri: Gösterip Yaptırma, Beyin Fırtınası |
| 4 | Endothelium in the regulation of vascular smooth muscle | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 5 | Neural transmission in vascular smooth muscle | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 6 | Ion channels in the smooth muscle | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 7 | Autonomic Innervation of Gastrointestinal System Tone | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Tartışma |
| 8 | Mid-Term Exam | prepare a presentation | Ölçme Yöntemleri: Ödev |
| 9 | Hormones And Autocoids Involving Into The Enteric System And Enteric System Tone | Review Literature and Books | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 10 | Gastrointestinal Smooth Muscle preparation: Isolated Gastric Fundus | Review literature | Öğretim Yöntemleri: Gösterip Yaptırma, Beyin Fırtınası |
| 11 | Drugs Affecting Bladder Autonomic Innervation, Bladder Function Disorders, and Bladder Smooth Muscle Tone | Review literature and textbook | Öğretim Yöntemleri: Anlatım, Beyin Fırtınası |
| 12 | Isolated Bladder Tissue | Review literature | Öğretim Yöntemleri: Gösterip Yaptırma, Soru-Cevap |
| 13 | Regulation of Corpus cavernosum smooth muscle | Review literature | Öğretim Yöntemleri: Anlatım, Tartışma |
| 14 | Drugs used in erectile dysfunction | Review textbook and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 15 | Isolated corpus cavernosum tissue | Review literature | Öğretim Yöntemleri: Gösterip Yaptırma, Beyin Fırtınası |
| 16 | Term Exams | Study to presentations | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Study to presentations | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 7 | 7 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 109 | ||
| Total Workload / 25 (h) | 4,36 | ||
| ECTS | 4 ECTS | ||