TÜRKÇE
ENGLISH
Information
| Code | EFR502 |
| Name | |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Doç. Dr. FATMA AYDINOĞLU
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Defines the anatomical parts of the autonomic nervous system, neurotransmitter and receptor types of the sympathetic and parasympathetic systems. Clarify to the synthesis, release, degradation and neurotransmitters of neurotransmitters in the Autonomic Nervous System. Explain and compare to the drugs that affect the autonomic nervous system by comparing their mechanism of action, side effects and contraindications.
Course Content
The anatomical parts of the autonomic nervous system, neurotransmitters of autonomic nervous system, the biosynthesis of autonomic nervous system neurotransmitters, their effects, mechanisms of action and drugs that affect the autonomic nervous system.
Course Precondition
None
Resources
Goodman - Gilman's The Pharmacological Basis of Therapeutics, Randa Hilal Dandan-Laurence L. Brunton Katzung, Basic & Clinical Pharmacology,2018 Whalen, Lippincott's Illustrated Reviews: Pharmacology, 2018
Notes
https://go.drugbank.com/
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Describe the anatomical and physiological features of the sympathetic nervous system and parasympathetic nervous system. |
| LO02 | Explain the synapses, junctions and receptors of the sympathetic and parasympathetic systems. |
| LO03 | Classify parasympathomimetic drugs and comprehend the pharmacological effects of these drugs. |
| LO04 | Classify parasympatholytic drugs and explain their pharmacological effects. |
| LO05 | Explain and compare to mechanism of action, side effects and contraindications of parasempatomimetic drugs. |
| LO06 | Explain and compare to mechanism of action, side effects and contraindications of parasempatholytic drugs. |
| LO07 | Classify sympathomimetic drugs and comprehend the pharmacological effects of these drugs. |
| LO08 | Classify sympatholytic drugs and explain their pharmacological effects. |
| LO09 | Explain and compare to mechanism of action, side effects and contraindications of Sempatomimetic drugs. |
| LO10 | Explain and compare to mechanism of action, side effects and contraindications of Sempatholytic drugs. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 4 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | 4 |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | 3 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Establishes a relationship between the effects, mechanisms of action and drug interactions of drugs. | 5 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | 5 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | 3 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Autonomic Nervous System | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 2 | Anatomy, Synapses, Junctions, Neurotransmitters and Receptors of the Autonomic Nervous System | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Beyin Fırtınası |
| 3 | Neurochemical Characteristics of the Cholinergic System The biosynthesis, storage, release and inactivation of acetylcholine, the acetylcholine receptors. | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 4 | Neurochemical Characteristics of the Adrenergic System the biosynthesis, storage, release and inactivation of noradrenaline, the Adrenergic Receptors | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 5 | Nonadrenergic noncholinergic nervous system neurotransmitters, Classification and General Properties of Autonomic Nervous System Drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 6 | Cholinomimetic Drugs: Parasympathomimetic drugs, classification and pharmacological effects | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 7 | Anticholinesterase drugs, anticholinesterase drug types and their pharmacological effects, clinical pharmacology of parasympathomimetic and anticholinesterase drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 8 | Mid-Term Exam | The subject should be prepare from literature and textbook. | Ölçme Yöntemleri: Ödev |
| 9 | Parasympathomimetic Drugs and their classification; Belladon Alkaloids, Pharmacokinetic Properties and Pharmacological Effects | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 10 | Synthetic Analogues of Belladon Alkaloids, Quaternary Amine Derivatives Pharmacological effects, side effects and contraindications Clinical Pharmacology of Parasympatholyic Drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 11 | Sympathomimetic Drugs and their classification; Pharmacokinetic properties, pharmacological effects and uses of catecholamine group drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Beyin Fırtınası |
| 12 | Pharmacological effects and uses of sympathomimetic amines (non-catecholamines) Clinical Pharmacology of Sympathomimetic Drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Anlatım |
| 13 | Sympatholytic Drugs; Classification, pharmacokinetic properties and pharmacological effects of adrenergic neuron blockers and adrenergic receptor blockers | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Nicotine and other ganglion stimulants; smoking and ganglion blocking drugs | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Student presentations, discussion and evaluation | The subject should be reviewed from the textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Should study presentations and textbooks | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 118 | ||
| Total Workload / 25 (h) | 4,72 | ||
| ECTS | 5 ECTS | ||