TÜRKÇE
ENGLISH
Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| TRANSLATIONAL MEDICINE (PhD) (ENGLISH) (INTERDISCIPLINARY) | |
| Code | Trans608 |
| Name | Animal Models of Diseases |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Dr. Öğr. Üyesi SİNAN KANDIR
(Güz)
(A Group)
(Ins. in Charge)
Dr. Öğr. Üyesi SİNAN KANDIR (Bahar) (A Group) (Ins. in Charge) |
Course Goal / Objective
This course aims to provide an in-depth understanding of the physiological and genetic characteristics of animal models used in translational medicine, including their applications in preclinical research, drug development, and disease modeling. It focuses on the selection of appropriate animal models, standardization of experimental design, power analysis, and ethical regulations.
Course Content
This course covers the selection and characterization of animal models used in translational medicine, physiological assessment of experimental animals, biotechnological applications in animal models, ethical principles in animal studies, and advanced preclinical research techniques.
Course Precondition
N/A
Resources
1. Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. 2. Advances in Animal Biotechnology, Singh B., Mal G., Gautam S.K., Mukesh M., 1st ed., Springer, 2019. 3. Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. 4. Principles of Cloning, Ed. Cibelli J., Gurdon J. et al., 2nd ed., Academic Press, 2014. 5. Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. and related literature
Notes
1. Animal Biotechnology Models in Discovery and Translation, Ed. Verma A.S, Singh A., 2nd ed., Academic Press, 2020. 2. Advances in Animal Biotechnology, Singh B., Mal G., Gautam S.K., Mukesh M., 1st ed., Springer, 2019. 3. Fundamentals of Laboratory Animal Science, Ed. Liu E., Fan J., 1st ed., CRC Press, 2018. 4. Principles of Cloning, Ed. Cibelli J., Gurdon J. et al., 2nd ed., Academic Press, 2014. 5. Transgenic Animal Technology, Ed. Pinkert, 3rd ed., Elsevier, 2014. and related literature
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Understands the role of animal models in translational research. |
| LO02 | Compares the physiological characteristics of different animal models. |
| LO03 | Selects and applies appropriate animal models for specific research purposes. |
| LO04 | Measures and evaluates physiological parameters in animal models. |
| LO05 | Understands and applies ethical regulations and the 3R principle. |
| LO06 | Analyzes the impact of genetic and environmental factors on disease models. |
| LO07 | Develops innovative approaches for disease modeling and experimental design. |
| LO08 | Evaluates the reliability and reproducibility of animal models in biomedical research. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops and deepens the current and advanced level knowledge of translational medicine via unique thoughts or researches at a level of proficiency, find out original definitions that will bring innovation in the field of translational medicine. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Conceives the interdisciplinary interactions related to translational medicine; analyzes synthesizes and evaluates original and new thoughts. | 5 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the usage of tool, devices and instruments requiered for knowledge and technologies about translational medicine and its related disciplines. | 2 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Defines frequently used statistical methods in translational medicine and related disciplines, uses statistical softwares effectively. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Uses both theoretical and practical knowledge at an advanced level in the studies related to translational medicine. | 4 |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Develops a new thoughts, method and designment/application which brings innovation in translational medicine or implements a known thoughts, method and designment/application in different fields, investigates, comprehends, designs, adapts, implements an original topic. | 5 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Writes the report of his/her research which he/she participated, | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Makes necessary investigations by using tool, devices and instrument required for knowledge and technologies about translational medicine and related disciplines at an advanced level, develops a new and creative solution (device, method, treatment, drug) for the problems. | 5 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Uses statistical software in the field of Translational Medicine effectively, chooses statistical methods correctly, calculates and interprets correctly. | |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Maintains the organization of Translational Medicine laboratories and develops solutions in case of encountering unforeseen complex situations during laboratory working hours. | 2 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducts scientific studies in translational medicine and related fields independently or as a team member. | 3 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Writes the report of his/her research in which he/she participated, publishes in a national or international reputed journal (indexing in SCI, SCI-Expanded, SSCI, or AHCI), and presents it at scientific meetings. | |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Follows evidence-based practices and conducts research on professional practices that will create evidence in their field. | |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Applies the principles of advanced professional development and lifelong learning in the field of Translational Medicine. | |
| PLO15 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicate current developments and studies within the field to both professional and non-professional groups systematically using written, oral and visual techniques by supporting with quantitative and qualitative data. | |
| PLO16 | Bilgi - Kuramsal, Olgusal | Learns how to teach a concept, subject, phenomenon or case related to Translational Medicine. | 3 |
| PLO17 | Belirsiz | Communicate and discuss orally, in written and visually with peers by using a foreign language at least at a level of European Language Portfolio B2 General Level. | |
| PLO18 | Yetkinlikler - Alana Özgü Yetkinlik | Audit the data gathering, interpretation, implementation and announcement stages by taking into consideration the cultural, scientific, and ethic values and uses these issues for social strategy, implementation plans and frame of quality processes. | |
| PLO19 | Yetkinlikler - Alana Özgü Yetkinlik | Knows the importance of ethical principles and ethical committees for the individual and society, acts ethically. | 5 |
| PLO20 | Yetkinlikler - Alana Özgü Yetkinlik | Increases the awareness of society about translational medicine. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to animal usage in translational medicine | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Laboratory animals (mice, rats) and their usage in translational medicine | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Laboratory animals (guinea pig, rabbit) and their usage in translational medicine | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama |
| 4 | Large animal models (pig, goat) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Large animal models (cow, sheep) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama |
| 6 | Zebrafish in translational research | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Aquatic animal models used in translational medicine (axolotl, alternative aquatic animals) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Tartışma, Alıştırma ve Uygulama |
| 8 | Biotechnological techniques used in animals (reproductive physiology, assisted reproductive techniques, embryo transfer techniques) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 9 | Transgenic laboratory animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Anlatım, Deney / Laboratuvar |
| 10 | Transgenic farm animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Transgenic aquatic animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası, Bireysel Çalışma, Problem Çözme |
| 12 | Alternative methods (in silico, in vitro, 3D organoids, microphysiological systems) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Tartışma, Soru-Cevap, Grup Çalışması, Örnek Olay, Problem Çözme, Proje Temelli Öğrenme |
| 13 | Design of animal experiments in translational research (choice of the right animal, PREPARE guidelines) | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama, Beyin Fırtınası, Örnek Olay |
| 14 | Ethical principles in the use of experimental animals (3R, 5R, 7R) and animal welfare | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay, Problem Çözme |
| 15 | Standardization, power analysis and biostatistics in animal models | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar |
| 16 | Humane Endpoints in experimental animals and necropsy | Related resources, lecture notes, and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 17 | Final exam | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Ödev, Proje / Tasarım, Performans Değerlendirmesi |
Assessment (Exam) Methods and Criteria
| Assessment Type | Midterm / Year Impact | End of Term / End of Year Impact |
|---|---|---|
| 1. Midterm Exam | 100 | 40 |
| General Assessment | ||
| Midterm / Year Total | 100 | 40 |
| 1. Final Exam | - | 60 |
| Grand Total | - | 100 |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 4 | 4 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 130 | ||
| Total Workload / 25 (h) | 5,20 | ||
| ECTS | 5 ECTS | ||