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Information
| Code | FİZ692 |
| Name | Experimental hypertension models |
| Term | 2024-2025 Academic Year |
| Term | Spring |
| Duration (T+A) | 2-2 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. BESİM ÖZAYKAN |
| Course Instructor |
1 |
Course Goal / Objective
To gain the necessary theoretical and practical knowledge and skills for the creation of experimental hypertension models
Course Content
Types of clinical hypertension and the mechanisms of their formation: A) extracellular fluid-induced experimental hypertension models in rats: a) Subtotal nephrectomy-salt hypertension; b) DOCA-salt hypertension, c) One kidney- one clip salt hypertension; B) Hypertension model in rats with increased renin: two kidney- one clip (Goldblatt) hypertension; application of surgical procedures which are related to the models, measurement of hemodynamic values in animals and discussion of the mechanism of development of hypertension
Course Precondition
To have taken undergraduate human physiology course
Resources
Guyton and Hall Textbook of Medical Physiology, 14th Edition
Notes
Articles on the subject
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Counts the main features of extracellular fluid-induced hypertension models in rats |
| LO02 | Applies surgical procedures related to experimental hypertension models |
| LO03 | Measures hemodynamic values in experimental hypertension models in rodents |
| LO04 | Understands the mechanism of occurrence of subtotal nephrectomy-salt hypertension |
| LO05 | Understands the mechanism of formation of one kidney-one clip salt hypertension |
| LO06 | Comprehends the mechanism of occurrence of hypertension in two kidney-clips (Goldblatt) |
| LO07 | Interprets the similarities and differences between the mechanisms of experimental hypertension models |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field of physiology with original thought and / or research at the level of expertise gained with the master degree and reach original definitions that will bring innovation to the field. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction in the field of physiology. Reaches original conclusions using knowledge requiring expertise in analyzing, synthesizing, and evaluating new and complex ideas | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Evaluates uses and analyzes the new information in the field of physiology with a systematic approach. | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Develops a new idea, method, design and / or application that brings innovation in the field of physiology or applies a known thought, method, design and / or application to a different area, researches, comprehends, designs and applies an original subject. | 5 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Uses the research methods in the field of physiology | 5 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Designs, manages, implements and concludes a study in the field of physiology independently | 5 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Makes scientific research in the field of physiology and / or extends the boundaries of knowledge in the field by producing or interpreting an original work | 2 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Develops new ideas and methods in the field of physiology by using mental processes such as creative and critical thinking, problem solving and decision making. | 3 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Keeps up-to-date knowledge by following scientific literature | 4 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the principle of lifelong learning and synthesizes the knowledge in his / her own field and other fields | |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops and discusses advanced written, oral and visual communication using at least one foreign language | 2 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Defends the original opinions and communicates effectively with experts | 2 |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Introduces scientific, technological, social or cultural advances in the field of physiology and contributes to the process of being and sustaining the society of the society | |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Establishes functional interaction by using strategic decision-making processes to solve problems encountered in the field of physiology | |
| PLO15 | Yetkinlikler - Öğrenme Yetkinliği | Contributes to the solution of social, scientific, cultural and ethical problems encountered in the field of physiology and supports the development of these values |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The main factors that determine blood pressure | Reading the relevant part of the basic physiology book; Reading related literature | Öğretim Yöntemleri: Anlatım |
| 2 | System disorders caused by blood pressure abnormalities | Reading the relevant part of the pathophysiology book; Reading related literature | Öğretim Yöntemleri: Anlatım |
| 3 | Basic features of clinical hypertension | Reading the relevant part of the pathophysiology book; Reading related literature | Öğretim Yöntemleri: Anlatım |
| 4 | Basic approaches in the treatment of clinical hypertension | Reading the related part of the book on internal diseases; Reading related literature | Öğretim Yöntemleri: Soru-Cevap |
| 5 | Basic characteristics of the experimental hypertension models which are the equivalences of clinical hypertension | Reading related literature | Öğretim Yöntemleri: Soru-Cevap |
| 6 | Similarities and differences between clinical and experimental hypertension induced by extracellular fluid expansion | Reading related literature | Öğretim Yöntemleri: Soru-Cevap |
| 7 | Mechanisms of formation of subtotal nephrectomy-salt hypertension | Reading related literature | Öğretim Yöntemleri: Soru-Cevap |
| 8 | Mid-Term Exam | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Deney / Laboratuvar |
|
| 9 | Application of surgical procedures for the formation of subtotal nephrectomy-salt hypertension in rats | Reading related literature | Öğretim Yöntemleri: Gösterip Yaptırma |
| 10 | Mechanisms of the formation of DOCA-salt hypertension | Reading related literature | Öğretim Yöntemleri: Gösterip Yaptırma, Anlatım |
| 11 | Application of surgical procedures for establishing DOCA-salt hypertension in rats | Reading related literature | Öğretim Yöntemleri: Gösterip Yaptırma |
| 12 | Mechanisms of the formation of two kidneys-one clip hypertension with high-renin | Reading related literature | Öğretim Yöntemleri: Anlatım |
| 13 | Application of surgical procedures for the formation of two kidneys-one clip hypertension with high-renin in rats | Reading related literature | Öğretim Yöntemleri: Gösterip Yaptırma |
| 14 | Measurement methods of hemodynamic values in hypertension models | Reading related literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Application of measurements of hemodynamic values in hypertension models | Reading related literature | Öğretim Yöntemleri: Gösterip Yaptırma |
| 16 | Term Exams | Öğretim Yöntemleri: Anlatım, Tartışma, Gösterip Yaptırma, Deney / Laboratuvar |
|
| 17 | Term Exams | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Gösterip Yaptırma |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 3 | 3 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 125 | ||
| Total Workload / 25 (h) | 5,00 | ||
| ECTS | 5 ECTS | ||