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Information
| Code | BİO603 |
| Name | Molecular Biology of the Cell - I (Z) |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 4-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. DAVUT ALPTEKİN |
| Course Instructor |
Prof. Dr. DAVUT ALPTEKİN
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Cell origins, evolution, the main methods used in the investigation and understanding of the basic components of the cell. Giving information about the structure and functions of cell membrane model, cytoplasm membrane and surface formation, Endoplasmic Retuculum, Golgiaparat, Lysosomes, Vocuol and Ribosomes, to understand the biosynthesis and degradation of cellular proteins.
Course Content
Origin and evolution of the cell. Prokaryotic cell; Model cell and model organisms. Basic molecular components of the cell. Enzymes, enzymatic interactions and regulation of catalytic activities. Biosynthesis of the cell's basic molecular. Cell membrane model and structure of plasma membrane. Transport of substances in the cell membrane, endocytosis and exocytosis. Cell surface formations, cell walls and extracellular matrix. Cell-cell, cell-matrix interactions. The structure and functions of endoplasmic retuculum, Golgi apparatus, Lysozyme and Central vacuole. Phagocytosis and autophagy. Structure and functions of ribosomes, Posttranslational changes of proteins. General enzyme and shearles, protein degradation, protein degradation.
Course Precondition
BİO501 Fundamentals of medical biology BİO 502 Fundamentals of medical genetics
Resources
G.M. Cooper, R.E. Housman. Hücre Moleküler Yaklaşım. Çeviri Editörleri; Neşe Atabey, Ersan Kalay, Meral Sakızlı, İzmir Tıp Kitabevi Kırtasiye Büro Malz. San. ve Tic.Ltd.Şti. RYedinci Baskı, 2016.
Notes
G.M. Cooper, R.E. Housman. Hücre Moleküler Yaklaşım. Çeviri Editörleri; Neşe Atabey, Ersan Kalay, Meral Sakızlı, İzmir Tıp Kitabevi Kırtasiye Büro Malz. San. ve Tic.Ltd.Şti. RYedinci Baskı, 2016.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Information about the origin and evolution of the cell will have the knowledge. |
| LO02 | Know the properties of prokaryotic and eukaryotic cells. |
| LO03 | Information about the molecular structure of the cell will have the knowledge. |
| LO04 | Information about the components of the cell will have the knowledge. |
| LO05 | Learn the structure and function of all organelles of the cell. |
| LO06 | Students will have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculty. |
| LO07 | Obtain the skills to conduct the laboratories of the Medical Biology and Genetics Courses at the undergraduate level. |
| LO08 | All cells in the human body will have the knowledge about their interactions with each other. |
| LO09 | Molecular structure of genetic material will be accumulated. |
| LO10 | They will be fully equipped with molecular techniques. |
| LO11 | Molecular-based knowledge will have some genetic diseases. |
| LO12 | Have knowledge about molecular genetic diseases, mendelian or non mendelian transition. |
| LO13 | Knowledge of molecular cell biology will have a broad level. |
| LO14 | Finding information gathered in research in Molecular subject will benefit from the savings. |
| LO15 | Information required in making and executing a project will have expertise and experience. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | 2 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | 2 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | 2 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | 5 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | 2 |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 2 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The origin and evoluation of the cell. | Preparing presentations | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Prokaryotic cell. The Model cell and model organisms. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 3 | Basic molecular components of the cell. Enzymes, enzymatic interactions and regulation of catalytic activities. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 4 | Biosynthesis of the cell's basic molecular. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 5 | Cell membrane model and structure of plasma membrane. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 6 | Transport of substances in the cell membrane, endocytosis and exocytosis. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 7 | Cell surface formations, cell walls and extracellular matrix. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 8 | Mid-Term Exam | Exam question preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Cell-cell and cell-matrix interactions. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 10 | Endoplasmic reticulum and Golgi apparatus. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 11 | The structure of lysozim and vocuole. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 12 | Fagositosis and otophagi, Vesicular transporting, | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 13 | Structure and fonction of ribosomes. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 14 | General enzyme and shearles, protein degradation, protein degradation. | Preparing presentations | Öğretim Yöntemleri: Anlatım |
| 15 | General review of topics. | To repeat the described issues | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Exam question preparation | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Exam question preparation | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 4 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 4 | 8 | 32 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 2 | 2 |
| Final Exam | 1 | 2 | 2 |
| Total Workload (Hour) | 148 | ||
| Total Workload / 25 (h) | 5,92 | ||
| ECTS | 6 ECTS | ||