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Information
| Code | BİO612 |
| Name | Epigenetics |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
This course aims to have knowledge about epigenetic regulations such as histone modifications and chromatin remodelling and learn role of epigenetics in development, formation of heterochromatin, imprinting and some diseases.
Course Content
History of Epigenetics, Concepts of Epigenetics, Chromatin Modifications and Their Mechanism of Action, Epigenetic studies in model organisms (Position Effect, Heterochromatin Formation, and Gene Silencing), The role of Polycomb and Trithorax Group Proteins in Epigenetics, Histone Variants and Epigenetics, Epigenetic Regulation of Chromosome Inheritance, Dosage Compensation in Mammals, DNA Methylation and Genomic Imprinting, Nuclear Transplantation and the Reprogramming of the Genome, Epigenetics and Human Disease, Cancer and Epigenetics, Epigenetic therapy, MIDTERM/FINAL EXAM
Course Precondition
Genome and proteome courses and cancer Biology and Genetics courses must be taken
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer 4- Epigenetics .C. David Allis. Cold Spring Harbour 2006.
Notes
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer 4- Epigenetics .C. David Allis. Cold Spring Harbour 2006.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows chromatin modifications. |
| LO02 | Knows role of epigenetics in embriogenesis and shaping bogy plan. |
| LO03 | Explains epigenetic regulations. |
| LO04 | Knows role of epigenetic mechanisms of genomic imprinting, gene silencing, kromatin remodelling |
| LO05 | Knows role of epigenetic in human diseases. |
| LO06 | Knows strategies of epigenetic therapy. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | 3 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | 3 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | 3 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 2 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | History of Epigenetics | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 2 | Concepts of Epigenetics | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 3 | Chromatin Modifications and Their Mechanism of Action | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 4 | Epigenetic studies in model organisms (Position Effect, Heterochromatin Formation, and Gene Silencing) | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 5 | The role of Polycomb and Trithorax Group Proteins in Epigenetics | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 6 | Histone Variants and Epigenetics | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 7 | Epigenetic Regulation of Chromosome Inheritance | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Preparation of multiple-choice questions | Ölçme Yöntemleri: Sözlü Sınav |
| 9 | Dosage Compensation in Mammals | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 10 | DNA Methylation and Genomic Imprinting | Slide preparation | Öğretim Yöntemleri: Anlatım |
| 11 | Nuclear Transplantation and the Reprogramming of the Genome | Slide preparation | Öğretim Yöntemleri: Anlatım |
| 12 | Epigenetics and Human Disease | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 13 | Epigenetics and Cancer epigenome | Slide preparation | Öğretim Yöntemleri: Tartışma, Anlatım |
| 14 | Cancer and Epigenetics | Slide preparation | Öğretim Yöntemleri: Anlatım |
| 15 | Epigenetic therapy | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 16 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Sözlü Sınav |
| 17 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 4 | 10 | 40 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 130 | ||
| Total Workload / 25 (h) | 5,20 | ||
| ECTS | 5 ECTS | ||