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Information
| Code | BİO611 |
| Name | Post Genetics |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
Investigation of complex diseases in terms of genetic and inheritance patterns.
Course Content
The results of genome projects, Postgenetic concept and its importance, Nuclear architecture and organization, Chromosome structures, Nucleus and chromosomal territoriums, Gene expression and control, Structure and properties of homeotic genes, Intersection of development-differentiation stem cells and diseases, Genomic imprinting, Isolator-silencer and imprint genes, Polycomb proteins and transcription, Post genetic diseases and their properties. Midterm /final exam
Course Precondition
Cancer Biology, Gene Genome and Proteome, Epigenetics courses taken and successfully completed
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Notes
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows post genetic concepts and importance of Post genetics. |
| LO02 | Knows importance of nuclear architecture and the territorium of chromosomes. |
| LO03 | Knows importance of territorium of chromosomes. |
| LO04 | Knows the intersection of growth, differentiation and stem cell related diseases. |
| LO05 | Knows post genetic diseases. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | 2 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | 4 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | 4 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | 3 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 3 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The results of genome projects | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 2 | Postgenetic concept and its importance | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 3 | Nuclear architecture and organization | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 4 | Chromosome structures | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 5 | Nucleus and chromosom interactions | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 6 | Nucleus and chromosomal territorium | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 7 | Importance of Gene expression | Slide preparation | Öğretim Yöntemleri: Soru-Cevap |
| 8 | Mid-Term Exam | Preparation of multiple-choice questions, oral exam | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Gene expression and control | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 10 | Structure and properties of homeotic genes | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 11 | Intersection of development-differentiation stem cells and diseases | Slide preparation | Öğretim Yöntemleri: Beyin Fırtınası |
| 12 | Role of stem cells in development-differentiation | Slide preparation | Öğretim Yöntemleri: Beyin Fırtınası |
| 13 | Genomic imprinting, Isolator-silencer and imprint genes | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 14 | Polycomb proteins and transcription | Slide preparation | Öğretim Yöntemleri: Soru-Cevap |
| 15 | Post genetic diseases and their properties | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 16 | Term Exams | Preparation of multiple-choice questions, oral exam | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Preparation of multiple-choice questions, oral exam | Ölçme Yöntemleri: Sözlü Sınav, Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 12 | 36 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 126 | ||
| Total Workload / 25 (h) | 5,04 | ||
| ECTS | 5 ECTS | ||