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Information
| Code | MEDF508 |
| Name | Radiobiology |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 7 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof.Dr. İSMAİL GÜNAY |
| Course Instructor |
1 |
Course Goal / Objective
Molecular and cell effects of radiation, cell survival curves, learning the effects of radiation dose-rate effects and applications
Course Content
Physics and chemistry of radiation absorption, Molecular mechanism of DNA and chromosome damage and repair, Cell survival curves, Radiation sensitivity and cell aging in mitotic cycle, Divided radiation and dose-rate effect, Oxygen effect and oxygenation, Radiation and cancer formation, Radiation inherited effects, Radiation embryo and fetuse effects, arasnav, final exam, assignments.
Course Precondition
The lesson has no prerequisites
Resources
Lecture notes (For Medical Faculty Students - İsmail Günay) Biophysics (Ferit Pehlivan) Biophysics (Gürbüz Çelebi)
Notes
Internet Search
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Physics and chemistry of radiation absorption |
| LO02 | Molecular mechanism of damage and repair of DNA and chromosome |
| LO03 | Cell survival curves |
| LO04 | Divided radiation and dose-rate effect |
| LO05 | Oxygen effect and oxygenation |
| LO06 | Hereditary effects of radiation |
| LO07 | Effects of radiation on embryo and fetus |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | List and explain the functions of health organizations; explains how national and international health institutions are organized; explains how clinics are managed. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Explains the technical infrastructure required for qualified service in the future of Medical Physics. | |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the European Community and national legal frameworks, regulations, guides and codes of practice related to the subject of Medical Physics. | 2 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Uses physical concepts, principles and theories in detail and numerically to explain structure, function, characteristics and limitations in fields covering Medical Physics; explains the use of medical devices in the field of medical physics. | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Explains the properties of ionizing radiation (electromagnetic, electrons, ions, neutrons) and other physical agents (electric energy, static electricity/magnetic fields, non-ionizing electromagnetic radiation, vibration, sound and ultrasound, laser) in detail and quantitatively. | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Explains the beneficial and adverse/harmful biological effects of ionizing radiation and different physical agents associated with medical devices numerically with biological models. Explain the factors affecting the magnitude of the biological effect. Explains ways of manipulation to improve clinical outcomes. | 3 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Explain deterministic/stochastic, early/late, teratogenic/genetic effects for each physical agent. | 2 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Makes a list from the literature on General Physics, Medical Physics and Health Physics in order to systematically review something in the field of Medical Physics practice. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | Applies the general concepts, principles and theories of physics to clinical problems related to the clinical use of medical devices, safety/risk management related to ionizing radiation. | 2 |
| PLO10 | Bilgi - Kuramsal, Olgusal | It uses the general concepts, principles and theories of physics to transfer new devices and related techniques to the clinical environment. | 3 |
| PLO11 | Bilgi - Kuramsal, Olgusal | It uses statistical packages for the analysis of clinical and biomedical data. | 2 |
| PLO12 | Bilgi - Kuramsal, Olgusal | Defines and explains the various dosimetric quantities used; explains the relationship between dosimetric quantities (energy flux, kerma, absorbed dose). | 3 |
| PLO13 | Bilgi - Kuramsal, Olgusal | Designs clinical and biomedical studies that are numerical and based on a rigorous statistical base. | 3 |
| PLO14 | Bilgi - Kuramsal, Olgusal | Determines the method during the delivery of ionizing radiation to the patient and designs different applications to improve this method. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Physics and chemistry of radiation absorption | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 2 | Damage of DNA and chromosome | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 3 | Repair of DNA and chromosome damages | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 4 | Molecular mechanism of damage and repair of DNA and chromosome | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 5 | Cell survival curves | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 6 | Evalıated of Cell survival curves | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 7 | Radiation sensitivity and cell aging in mitotic cycle | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Yazılı Sınav |
|
| 9 | Divided radiation dose | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 10 | Divided radiation and dose-rate | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 11 | Divided radiation and dose-rate effect | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 12 | Effect of oxygen on radiation | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 13 | Oxygen effect and oxygenation | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 14 | Radiation and cancer formation | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 15 | Hereditary effects of radiation | Student reads the related section in advance | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay |
| 16 | Term Exams | Studying the lessons taught throughout the semester | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Studying the lessons taught throughout the semester | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 5 | 10 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 18 | 18 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 170 | ||
| Total Workload / 25 (h) | 6,80 | ||
| ECTS | 7 ECTS | ||