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Information
| Code | FAR523 |
| Name | Pharmacogenetics: Drug metabolism according to genetic variation |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. MEHMET ATA SEÇİLMİŞ |
Course Goal / Objective
To teach the effects of genetic variations on drug responses and the principles of pharmacogenetics. By understanding how genetic variations affect drug metabolism, students will gain the ability to provide more effective and safe treatment options to patients.
Course Content
The role of pharmacogenetics in variability in drug response, Genomic basis of pharmacogenetics, Ethnic and race-specific polymorphism, Pharmacogenetic studies.
Course Precondition
none
Resources
1. Basic and Clinical Pharmacology (Katzung), 2. The Pharmacologıcal Basıs of Therapeutıcs (Goodman and Gilman), 3. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, Editör: Prof. Dr. S. Oğuz Kayaalp
Notes
Internet and library databases
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Evaluates the contribution of genetic and environmental factors to interindividual variability |
| LO02 | Gaining knowledge about the polymorphism of various enzymes that activate and inactivate drugs through biotransformation. |
| LO03 | Knows the changes in drug pharmacokinetics and pharmacodynamics due to genetic factors |
| LO04 | Know the situations that depend on genetic differences in the tendency of enzymes to be induced or inhibited. |
| LO05 | Knows the role of genetic polymorphism in changes in response to drug therapy. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Ability to use the concepts of pharmacology, pharmacokinetics and pharmacodynamics | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Establishes relationships between drug effects, mechanisms of action, and drug interactions | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the side effects and toxic effects of drugs | 2 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | Uses an experimental setup for an in vitro or in vivo pharmacological study | 1 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Follows scientific literature related to his/her field | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes part in the design, maintenance and analysis of data of a research related to his/her field. | 1 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Is aware of the importance of scientific research ethics. | |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Expresses scientific thought analytically and establishes hypotheses. | |
| PLO09 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes part in the statistical evaluation of data. | 1 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Aware of the importance of rational drug use | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Elimination of the contribution of genetic and environmental factors to interindividual variability in drug responses | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Investigation of polymorphism of enzymes involved in drug biotransformation - I | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Investigation of polymorphism of enzymes involved in drug biotransformation - II | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Factors affecting drug metabolism: genetic polymorphism and environmental factors | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Changes in drug pharmacokinetics due to genetic factors - I | Pharmacology textbooks | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 6 | Changes in drug pharmacokinetics due to genetic factors -II | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Changes in drug pharmacodynamics due to genetic factors III | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Pharmacology textbooks | Ölçme Yöntemleri: Ödev |
| 9 | Effect of genetic polymorphism on the tendency for enzymes to be induced or inhibited depending on environmental factors and dietary habits. | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Changes in drug pharmacokinetics due to genetic factors | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | The importance of pharmacogenetics for personalized treatment | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Tamoxifen use and its importance in terms of CYP2D6 polymorphism | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Clopidogrel use and its importance in terms of CYP2C19 polymorphism | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Literature reviews, article presentations and discussions - I | Pharmacology textbooks | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Literature reviews, article presentations and discussions - II | Pharmacology textbooks | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 16 | Term Exams | Pharmacology textbooks | Ölçme Yöntemleri: Sözlü Sınav |
| 17 | Term Exams | Pharmacology textbooks | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 24 | 24 |
| Total Workload (Hour) | 88 | ||
| Total Workload / 25 (h) | 3,52 | ||
| ECTS | 4 ECTS | ||