TÜRKÇE
ENGLISH
Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOLOGY (MASTER) (WITH THESIS) | |
| Code | BY776 |
| Name | Molecular Biology of Cell Death |
| Term | 2025-2026 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. SADIK DİNÇER |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
403 The types of pathological cell death, which occur physiologically during development or are known as a fundamental factor in the onset of diseases and aging, their transition points, interrelationships, and molecular mechanisms should be taught in detail. This will lay the foundation for developing therapeutic approaches to different pathologies.
Course Content
Identifying the basic types of cell death and learning their key characteristics: apoptosis, necrosis, autophagy, pyroptosis, ferroptosis, cuproptosis, mitophagy, necroptosis, neptosis, entoxosis, paraptosis, methoxosis, mithoptosis, parthenoptosis, anoikis; the importance of cellular organelles in cell death mechanisms: mitochondrial Ca+2 and cell death; the importance of cell death receptors; cell death proteins; cell damage, inflammation, degradation processes, senescence, and cell death; signaling pathways leading to cell death and their commonalities; molecular mechanisms in the regulation of cell death pathways; the role of cell cycle control in cell death.
Course Precondition
None
Resources
Current publications
Notes
1. Gerry Melino, David Vaux, eds. Cell Death. Wiley, 2010. 2. Hao Wo, ed. Cell Death: Mechanism and Disease. Springer, 2014. 3. Douglas R Green, ed. Means to an End: Apoptosis and Other Cell Death Mechanisms. 2010. 4. Current literature related to the topic.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | It explains and compares the types of cell death. |
| LO02 | It explains the molecular mechanisms of fundamental cell death mechanisms. |
| LO03 | It explains other types of cell death and their molecular mechanisms. |
| LO04 | It explains the molecular mechanisms of autophagic cell death and downstream organelle-targeted autophagic death. |
| LO05 | It associates all types of cell death with various diseases. |
| LO06 | This section explains the role of cellular organelles in cell death mechanisms, proteins associated with cell death mechanisms, and cell death receptors. |
| LO07 | It explains cell damage, cell death, cell damage repair, and regeneration. |
| LO08 | It explains the molecular mechanisms involved in the regulation of cell death pathways. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the undergraduate level qualifications, develops and deepens the knowledge in the same or different field at the level of expertise and analyzes and interprets them using statistical methods. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Identifies the interdisciplinary interaction that the field is related to. | 5 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Interprets the knowledge gained in the field by integrating the information from different disciplines and creates new information. | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Carries out a study that requires expertise related to the field independently. | 5 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Evaluates the knowledge and skills acquired at the level of expertise in the field with a critical approach and directs its learning. | 5 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Supports the current developments in the field and their studies with quantitative and qualitative data and transmits them both in the field and outside the field systematically in written, oral and visual form. | 5 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | It supervises the social, scientific, cultural and ethical values in the collection, interpretation, application and announcement stages of the data related to the field and teaches these values. | 5 |
| PLO08 | Bilgi - Kuramsal, Olgusal | The information they absorbed in the field; use problem solving and / or practical skills in interdisciplinary studies. | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | 5 |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Apoptosis and its Molecular Mechanism I | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Apoptosis and its Molecular Mechanism II | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 3 | Necrosis and its Molecular Mechanism | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | Autophagy and its Molecular Mechanism | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Ferroptosis and its Molecular Mechanism | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Mitochondria-related cell death types (mitoptosis, parthanatosis, and mitophagy) and their molecular mechanisms. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Immune pathogenesis-related cell death types (pyroptosis and nethosis) and their molecular mechanisms. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | ||
| 9 | |||
| 10 | |||
| 11 | |||
| 12 | |||
| 13 | |||
| 14 | |||
| 15 | |||
| 16 | Term Exams | ||
| 17 | Term Exams |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||