TÜRKÇE
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Information
| Code | Trans557 |
| Name | Biomarkers and Precised Medicine (Z) |
| Term | 2022-2023 Academic Year |
| Term | Spring |
| Duration (T+A) | 1-4 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | İngilizce |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
1 |
Course Goal / Objective
From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, the course will walk students through the many aspects of precision medicine, from the bench to the bedside and to population health
Course Content
This course will provide students with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues.
Course Precondition
Resources
Notes
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The students who attend this course will understand the state of art of and explain current challenges in diagnosis, follow-up and therapy of diseases in the selected case scenarios and can tell the reasons why biomarkers and personalized medicine is needed. |
| LO02 | They will learn the procedures to discover biomarkers and , how to analyze their efficacy |
| LO03 | Students will write a sample protocol in their choice of area to develop and test a biomarker |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops and deepens knowledge in the field of translational medicine to the proficiency level based on bachelor-level qualifications. | 5 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Conceives the interdisciplinary interaction in which the field is related to translational medicine | 5 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Knows the information technologies, technical equipment, and field-specific devices and instruments at the level required by the field of Translational Medicine. | 5 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Knows statistics as a tool that is constantly used in studies in the field of Translational Medicine, and uses relevant software effectively. | 5 |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Uses of theoretical and practical knowledge within the field at a proficiency level. | 5 |
| PLO06 | Beceriler - Bilişsel, Uygulamalı | Interprets the knowledge about the field by integrating the information gathered from different disciplines and formulates new knowledge. | 5 |
| PLO07 | Beceriler - Bilişsel, Uygulamalı | Makes necessary investigations by using tools, devices, and instruments required for knowledge and technologies about translational medicine and related disciplines at an advanced level; develops a new and creative solution (device, method, treatment, drug) for the problems. | 4 |
| PLO08 | Beceriler - Bilişsel, Uygulamalı | Solves the problem faced related to the field by using research methods. | 3 |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Plans and conducts an experimental study. | 3 |
| PLO10 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes responsibility and develops new strategic solutions as a team member in order to solve unexpected complex problems faced within the applications in the field, evaluates the results, and applies when necessary. | 4 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducts scientific studies in translational medicine and related fields independently or as a team member. | 4 |
| PLO12 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Publishes a scientific paper in a national journal or presents it at a scientific meeting. | 3 |
| PLO13 | Yetkinlikler - Öğrenme Yetkinliği | Evaluates knowledge and skills acquired at proficiency level in the field with a critical approach and direct the learning. | 5 |
| PLO14 | Yetkinlikler - Öğrenme Yetkinliği | Applies the principles of advanced professional development and lifelong learning in the field of Translational Medicine. | 5 |
| PLO15 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates current developments and studies within the field to both professional and non-professional groups systematically using written, oral and visual techniques by supporting quantitative and qualitative data. | 5 |
| PLO16 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates and discusses orally, in writing, and visually with peers by using a foreign language at least at a level of European Language Portfolio B2 General Level. | 5 |
| PLO17 | Yetkinlikler - Alana Özgü Yetkinlik | Develops strategy, policy, and implementation plans on the issues related to the field and assess the findings within the frame of quality processes and ethics. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Understanding Biomarkers and Precised Medicine terminology | Öğretim Yöntemleri: Anlatım |
|
| 2 | Human genome variabilty and phenotype consequences | Öğretim Yöntemleri: Tartışma |
|
| 3 | New generation sequencing and liquid biopsy techniques | Öğretim Yöntemleri: Deney / Laboratuvar |
|
| 4 | Rare genetic disorder and precision medicine | Öğretim Yöntemleri: Grup Çalışması |
|
| 5 | Biomarker discover methodologies | Öğretim Yöntemleri: Anlatım |
|
| 6 | Article presentations related to biomarker discovery | Öğretim Yöntemleri: Grup Çalışması |
|
| 7 | Case study | Öğretim Yöntemleri: Grup Çalışması |
|
| 8 | Mid-Term Exam | Ölçme Yöntemleri: Sözlü Sınav |
|
| 9 | Liquid chromatography and mass spectrometry studies - I | Öğretim Yöntemleri: Deney / Laboratuvar |
|
| 10 | Liquid chromatography and mass spectrometry studies - II | Öğretim Yöntemleri: Deney / Laboratuvar |
|
| 11 | Biomarker discovery proposal workshop - I | Öğretim Yöntemleri: Grup Çalışması |
|
| 12 | Stutents' Proposal presentations | Öğretim Yöntemleri: Bireysel Çalışma |
|
| 13 | Biomarker discovery proposal workshop - II | Öğretim Yöntemleri: Bireysel Çalışma |
|
| 14 | Evidence-Based Precision Medicine | Öğretim Yöntemleri: Grup Çalışması |
|
| 15 | New Technologies and Personalized Health: Opportunities and Challenges | Öğretim Yöntemleri: Tartışma |
|
| 16 | Term Exams | ||
| 17 | Term Exams |