ECF212 Biochemistry II

3 ECTS - 2-0 Duration (T+A)- 4. Semester- 2 National Credit

Information

Code ECF212
Name Biochemistry II
Term 2023-2024 Academic Year
Semester 4. Semester
Duration (T+A) 2-0 (T-A) (17 Week)
ECTS 3 ECTS
National Credit 2 National Credit
Teaching Language Türkçe
Level Lisans Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Doç. Dr. ÖZLEM ALPTEKİN
Course Instructor Doç. Dr. ÖZLEM ALPTEKİN (A Group) (Ins. in Charge)


Course Goal / Objective

To learn the carbohydrate, lipid, protein and nucleic acid metabolism (production and destruction), to relate to the basic principles of bioenergetics, to relate metabolic pathways, to understand the fundamentals of genetic information transfer.

Course Content

Informations about bioenergetics and metabolism, glycolysis, gluconeogenesis, and the pentose phosphate pathway, principles of metabolic regulation, the citric acid cycle, fatty acid catabolism, amino acid oxidation and the production of urea, oxidative phosphorylation and photophosphorylation, lipid biosynthesis, biosynthesis of amino acids, nucleotides, and related molecules, integration and hormonal regulation of mammalian metabolism, DNA metabolism, RNA metabolism, protein metabolism will be given in this lesson.

Course Precondition

There is no prerequisite.

Resources

Nelson David L. Lehninger Biyokimyanın İlkeleri Palme Yayıncılık 2013 ISBN 9758982188, Berg Jeremy Mark Biyokimya (Stryer) Palme Yayınevi 2013 ISBN 9786053552024 Erden İnal Mine Marks Temel Tıbbi Biyokimyası Klinik Yaklaşım Güneş Tıp Kitabevi 2007 ISBN 9789752771383 Bender Murray Harper Biyokimya Nobel Tıp Kitabevi 2015 ISBN 9786053351542

Notes

Alptekin Ö, lecture notes uploaded to ÇÜBİS system, 2022


Course Learning Outcomes

Order Course Learning Outcomes
LO01 She/He makes the definitions of anabolism, catabolism, metabolism, metabolite.
LO02 She/He shows the reaction steps of glycolysis.
LO03 She/He explains the relationship between glycolysis and gluconeogenesis.
LO04 She/He explains the importance of the pentosephosphate pathway.
LO05 She/He explains the steps in the regulation of metabolic pathways.
LO06 She/He explains the enzymes involved in glycogen storage diseases in humans.
LO07 She/He explains the regulation of the citric acid cycle.
LO08 She/He explains the basic steps in the digestion, absorption, transport and storage of fats.
LO09 She/He explains the relationship between atherosclerosis and LDL.
LO10 She/He explains the regulation mechanisms of fatty acid oxidation.
LO11 She/He explains the 3 basic pathways in the oxidative breakdown of amino acids..
LO12 She/He explains the reaction steps in urea production.
LO13 She/He explains phenylalanine and tyrosine degradation pathways and diseases that occur due to damage to enzymes in these pathways.
LO14 She/He explains the chemiosmotic model in ATP synthesis.
LO15 She/He calculates the yield of ATP gained from the complete oxidation of glucose.
LO16 She/He explains the regulation mechanisms in the synthesis of fatty acids.
LO17 She/He explains the hormonal control of TAG synthesis.
LO18 She/He explains the relationship between HMG-CoA reductase enzyme and statins.
LO19 She/He explains the relationship between defects in glycine-prophyrin synthesis steps and porphyrias.
LO20 She/He explains in the catabolism of purine nucleotides.


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal Have sufficient knowledge in pharmaceutical field and develop the knowledge. 2
PLO02 Bilgi - Kuramsal, Olgusal Comprehends professional knowledge with ethical responsibility through current laws and legislation.
PLO03 Beceriler - Bilişsel, Uygulamalı Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach.
PLO04 Beceriler - Bilişsel, Uygulamalı Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning.
PLO05 Beceriler - Bilişsel, Uygulamalı Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, 3
PLO06 Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education.
PLO07 Yetkinlikler - Öğrenme Yetkinliği Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. 2
PLO08 Yetkinlikler - Öğrenme Yetkinliği Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. 4
PLO09 Yetkinlikler - İletişim ve Sosyal Yetkinlik Communicates effectively in writing and speaking.
PLO10 Yetkinlikler - İletişim ve Sosyal Yetkinlik Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language.
PLO11 Yetkinlikler - İletişim ve Sosyal Yetkinlik Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity
PLO12 Yetkinlikler - Alana Özgü Yetkinlik Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field.
PLO13 Yetkinlikler - Alana Özgü Yetkinlik Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. 2
PLO14 Yetkinlikler - Alana Özgü Yetkinlik Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. 3


Week Plan

Week Topic Preparation Methods
1 Bioenergetics and metabolism Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
2 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
3 Principles of Metabolic Regulation Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
4 The Citric Acid Cycle Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
5 Fatty Acid Catabolism Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
6 Amino Acid Oxidation and the Production of Urea Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
7 Oxidative Phosphorylation and Photophosphorylation Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
8 Mid-Term Exam Re-studying the topics covered in the course from the relevant textbooks and lecture notes. Ölçme Yöntemleri:
Yazılı Sınav
9 Lipid Biosynthesis Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
10 Biosynthesis of Amino Acids, Nucleotides, and Related Molecules Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
11 Integration and Hormonal Regulation of Mammalian Metabolism Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
12 DNA Metabolism Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
13 RNA Metabolism Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
14 Protein Metabolism Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap, Tartışma
15 Drug development Textbooks and lecture notes Öğretim Yöntemleri:
Anlatım, Soru-Cevap
16 Term Exams Re-studying the topics covered in the course from the relevant textbooks and lecture notes. Ölçme Yöntemleri:
Yazılı Sınav
17 Term Exams Re-studying the topics covered in the course from the relevant textbooks and lecture notes. Ölçme Yöntemleri:
Yazılı Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 2 28
Out of Class Study (Preliminary Work, Practice) 14 2 28
Assesment Related Works
Homeworks, Projects, Others 0 0 0
Mid-term Exams (Written, Oral, etc.) 1 6 6
Final Exam 1 16 16
Total Workload (Hour) 78
Total Workload / 25 (h) 3,12
ECTS 3 ECTS

Update Time: 03.05.2023 02:13