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Information
| Code | BMM016 |
| Name | Regenerative Medicine and Stem Cell Applications |
| Term | 2023-2024 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Öğr. Gör.Dr. DİLEK SÖNMEZER |
Course Goal / Objective
The aim of this course is to give the basic information necessary to develop new treatment methods at tissue and organ level by utilizing the potential of use of stem cells in regenerative medicine approaches.
Course Content
Introduction to Molecular and cellular biology, Basic Features of Stem Cells and Stem Cell Niches, Mechanism of Sem Cell Self Renewal, Cell Cycle Regulators in Stem Cells, Cell Fusion and Differentiated State, Phenotype Changing Mechanism of Stem Cells, Induced Pluripotent Stem Cells, Role of Stem Cell in Regenerative Medicine, Stem Cells in Treatment of Myocardial Infarction and Cardiomyopathy, Mesenchymal Stem Cells in Cancer Therapy, Stem Cells in Spinal Cord Regeneration, Stem Cells Therapy for Optic Nerve Regeneration, Stem Cells Therapy for Cartilage Regeneration, Ethical Considerations
Course Precondition
None
Resources
1. Essentials of Stem Cell Biology 3rd edition. John Gearhart, Brigid Hogan, Douglas Melton, Roger Pedersen, E. Donall Thomas, James Thomas, Sir Ian Wilmut.
Notes
1. Stem Cells: Basics and Clinical Translation 1st Ed Robert Chunhua Zhao, Springer 2015
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Comprehends the difference between stem cells and normal cells in terms of their biological structure and properties. |
| LO02 | Learns the self-renewal and differentiation mechanisms of stem cells. |
| LO03 | Gain knowledge about the concept of regenerative medicine. |
| LO04 | Learns the applications of stem cells in regenerative medicine. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To be able to solve scientific problems encountered in the field of medicine and medical technologies by applying current and advanced technical approaches of mathematics, science and engineering sciences. | 4 |
| PLO02 | Yetkinlikler - Öğrenme Yetkinliği | To have a knowledge of the literature related to a sub-discipline of biomedical engineering, to define and model current problems. | 5 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Ability to analyze data, design and conduct experiments, and interpret results | |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Developing researched contemporary techniques and computational tools for engineering applications | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | To be able to analyze and design a process in line with a defined target | 4 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Conducting scientific studies with a medical doctor from an engineering perspective. | 3 |
| PLO07 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Expressing own findings orally and in writing, clearly and concisely. | 3 |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | To be able to improve oneself by embracing the importance of lifelong learning and by following the developments in science-technology and contemporary issues. | |
| PLO09 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Ability to act independently, set priorities and creativity. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Being aware of national and international contemporary scientific and social problems in the field of Biomedical Engineering. | |
| PLO11 | Yetkinlikler - Alana Özgü Yetkinlik | To be able to evaluate the contribution of engineering solutions to problems in medicine, medical technologies and health in a global and social context. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to Molecular and cellular biology | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Beyin Fırtınası, Bireysel Çalışma |
| 2 | Basic Features of Stem Cells and Stem Cell Niches | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Bireysel Çalışma |
| 3 | Mechanism of Sem Cell Self Renewal | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Beyin Fırtınası, Bireysel Çalışma, Problem Çözme |
| 4 | Cell Cycle Regulators in Stem Cells | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Beyin Fırtınası, Bireysel Çalışma |
| 5 | Cell Fusion and Differentiated State | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Beyin Fırtınası, Problem Çözme |
| 6 | Phenotype Changing Mechanism of Stem Cells | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması, Benzetim, Bireysel Çalışma |
| 7 | Induced Pluripotent Stem Cells | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Beyin Fırtınası |
| 8 | Mid-Term Exam | Read about the subject. | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 9 | Role of Stem Cell in Regenerative Medicine | Read about the subject. | Öğretim Yöntemleri: Soru-Cevap, Anlatım, Benzetim, Beyin Fırtınası, Bireysel Çalışma, Problem Çözme |
| 10 | Stem Cells in Treatment of Myocardial Infarction and Cardiomyopathy | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Bireysel Çalışma |
| 11 | Mesenchymal Stem Cells in Cancer Therapy | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Grup Çalışması, Benzetim, Beyin Fırtınası, Tartışma |
| 12 | Stem Cells in Spinal Cord Regeneration | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim |
| 13 | Stem Cells Therapy for Optic Nerve Regeneration | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Beyin Fırtınası |
| 14 | Stem Cells Therapy for Cartilage Regeneration | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Benzetim, Bireysel Çalışma, Tartışma |
| 15 | Ethical Considerations | Read about the subject. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Benzetim, Beyin Fırtınası, Grup Çalışması |
| 16 | Term Exams | Read about the subject. | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
| 17 | Term Exams | Read about the subject. | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 5 | 5 | 25 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 2 | 2 |
| Final Exam | 1 | 2 | 2 |
| Total Workload (Hour) | 141 | ||
| Total Workload / 25 (h) | 5,64 | ||
| ECTS | 6 ECTS | ||