TÜRKÇE
ENGLISH
Information
| Code | ECF211 |
| Name | Biochemistry I |
| Term | 2024-2025 Academic Year |
| Semester | 3. Semester |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. ÖZLEM ALPTEKİN |
| Course Instructor |
Doç. Dr. ÖZLEM ALPTEKİN
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Understanding the basic knowledge of biomolecules in living systems, comprehending structure, function and functions of biomolecules in organism, genetic information storage, transfer and regulation of gene expression.
Course Content
Informations about the foundations of biochemistry, water, amino acids, peptides and proteins, the three-dimensional structure of proteins, protein function, enzymes and their kinetics, carbohydrates and glycobiology, nucleotides and nucleic acids, DNA-based information technologies, lipids, biological membranes and transport and biosignaling will be given in this lesson.
Course Precondition
There is no prerequisite.
Resources
Nelson David L. Lehninger Biyokimyanın İlkeleri Palme Yayıncılık 2013 ISBN 9758982188, Berg Jeremy Mark Biyokimya (Stryer) Palme Yayınevi 2013 ISBN 9786053552024 Erden İnal Mine Marks Temel Tıbbi Biyokimyası Klinik Yaklaşım Güneş Tıp Kitabevi 2007 ISBN 9789752771383 Bender Murray Harper Biyokimya Nobel Tıp Kitabevi 2015 ISBN 9786053351542
Notes
Alptekin Ö, lecture notes uploaded to ÇÜBİS system, 2022
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | She/He explains the cellular, chemical, physical, genetic and evolutionary foundations. |
| LO02 | She/He explains the effect of pH on solubility in biological systems. |
| LO03 | She/He explains the importance of water in life. |
| LO04 | She/He calculates the net charge of an amino acid based on the ambient pH. |
| LO05 | She/He can give examples of amyloidosis caused by defects in protein folding. |
| LO06 | She/He explains the structures of myoglobin, α-creatine and collagen proteins. |
| LO07 | She/He explains the positive and negative cooperative relationship between protein ligand. |
| LO08 | She/He associates sickle cell anemia with a change in the primary structure of hemoglobin. |
| LO09 | She/He explains the key-lock hypothesis and stimulated-fit model in enzyme activity. |
| LO10 | She/He infers Michaelis-Menten kinetics in enzyme kinetics. |
| LO11 | She/He explains the types of enzyme inhibition. |
| LO12 | She/He makes the definition of carbohydrates and explains their biological functions. |
| LO13 | She/He explains the structure of important polysaccharides in biological systems. |
| LO14 | She/He explains the differences between DNA and RNA. |
| LO15 | She/He makes the functional definition of lipids. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 2 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | |
| PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | 2 |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 2 |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | |
| PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | 4 |
| PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | |
| PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
| PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
| PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | |
| PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 3 |
| PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | The Foundations of Biochemistry | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Water | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Amino Acids, Peptides and Proteins | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 4 | The Three-Dimensional Structure Of Proteins | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Protein Function | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 6 | Enzymes | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 7 | Enzymes and their kinetics | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Problem Çözme |
| 8 | Mid-Term Exam | Re-studying the topics covered in the course from the relevant textbooks and lecture notes. | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Carbohydrates And Glycobiology | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Problem Çözme |
| 10 | Nucleotides and Nucleic Acids | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | DNA-Based Information Technologies | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 12 | Lipids | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 13 | Biological Membranes and Transport | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | Biosignaling | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Signal-Transduction Pathways | Textbooks and lecture notes | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exams | Re-studying the topics covered in the course from the relevant textbooks and lecture notes. | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Re-studying the topics covered in the course from the relevant textbooks and lecture notes. | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 78 | ||
| Total Workload / 25 (h) | 3,12 | ||
| ECTS | 3 ECTS | ||