Information
Code | ECF413 |
Name | Pharmaceutical Toxicology |
Term | 2024-2025 Academic Year |
Semester | 7. Semester |
Duration (T+A) | 2-0 (T-A) (17 Week) |
ECTS | 3 ECTS |
National Credit | 2 National Credit |
Teaching Language | Türkçe |
Level | Lisans Dersi |
Type | Normal |
Mode of study | Yüz Yüze Öğretim |
Catalog Information Coordinator | Dr. Öğr. Üyesi Göksun DEMİREL |
Course Instructor |
Dr. Öğr. Üyesi Göksun DEMİREL
(A Group)
(Ins. in Charge)
Anıl YİRÜN (A Group) (Asst. Ins.) |
Course Goal / Objective
Comprehends the importance of basic toxicology and special toxicology issues. Explain the importance of target organ toxicity, xenobiotic toxicity and poisoning, including drugs.
Course Content
History of toxicology and general concepts; toxicity tests; toxicokinetics; mechanisms of toxic effects; factors affecting toxicity; classification of toxic effects; genotoxic effects and factors; teratogenicity and teratogenic compounds; carcinogenicity and carcinogenic compounds; allergic reactions and immunotoxic effect; genetic polymorphism; toxicological evaluation of drug-drug, drug-disease, drug-nutrient interactions; acute poisoning treatment.
Course Precondition
None
Resources
1.Klaassen, C.D., Watkins J.W., "Casarett & Doull?s Essential of Toxicology, The McGraw Hill Companies, 2010. 2.Ellenhorn, M.J., "Medical Toxicology", Williams & Wilkins, Maryland, 1997. 3.Hayes, A.W., "Principles and Methods of Toxicology", Taylor & Francis, Philadelphia, 2001
Notes
Vural N., Toxicology, Ankara University Publishing
Course Learning Outcomes
Order | Course Learning Outcomes |
---|---|
LO01 | Explain the basic concepts of toxicology. |
LO02 | Comprehends the issues of toxicokinetics, mechanisms of toxic action. |
LO03 | Comprehends the specific toxic effects and toxic consequences of genetic polymorphism. |
LO04 | Explains the toxicological evaluation of drug-drug, drug-food interactions. |
LO05 | List the general principles of acute poisoning treatment. |
LO06 | Comprehends the subject of target organ toxicity. |
LO07 | Discusses the poisonings observed with drugs and other xenobiotics and treatment approaches. |
LO08 | Compares the toxic effects of biotechnological products and nanotoxicology. |
Relation with Program Learning Outcome
Order | Type | Program Learning Outcomes | Level |
---|---|---|---|
PLO01 | Bilgi - Kuramsal, Olgusal | Have sufficient knowledge in pharmaceutical field and develop the knowledge. | 4 |
PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends professional knowledge with ethical responsibility through current laws and legislation. | |
PLO03 | Beceriler - Bilişsel, Uygulamalı | Provides consultancy service to patients, community and health care personnel and evaluates advanced knowledge and skills with a critical approach. | 5 |
PLO04 | Beceriler - Bilişsel, Uygulamalı | Possessing the knowledge of historical and current developments in the field of Pharmacy, monitoring, evaluation and application of scientific and evidence-based data, and adopting lifelong learning. | 1 |
PLO05 | Beceriler - Bilişsel, Uygulamalı | Have the knowledge and skills to help provide patient-oriented pharmacy applications and individualized pharmaceutical care by learning the basics of Clinical Pharmacy, | |
PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Takes a role in the evaluation and analysis of the events and cases related to the development of pharmacy profession and education. | 1 |
PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Integrates and develops professional knowledge via different disciplines and uses the acquired knowledge to improve the health level and quality of life of the community. | 3 |
PLO08 | Yetkinlikler - Öğrenme Yetkinliği | Use effectively the concepts and applications of basic sciences and basic medical sciences in the field of medicine and pharmacy and update the information. | |
PLO09 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Communicates effectively in writing and speaking. | |
PLO10 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Practices the profession in accordance with Atatürk's principles and reforms, equipped with universal knowledge, uses Turkish correctly and knows at least one foreign language. | |
PLO11 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Be an example to society withexternal appearance, demeanor, attitude and behavior for the other professionals and society and with professional identity | |
PLO12 | Yetkinlikler - Alana Özgü Yetkinlik | Have knowledge about health policies and health economics, pharmacy management and define the problems in pharmaceutical field. | 3 |
PLO13 | Yetkinlikler - Alana Özgü Yetkinlik | Interprets information about current health and treatment problems and attends meeting on related matters . Plays an active role in community health. | 4 |
PLO14 | Yetkinlikler - Alana Özgü Yetkinlik | Acquires basic information about diseases, makes decisions about the drugs used in treatment in accordance with rational drug use. | 3 |
Week Plan
Week | Topic | Preparation | Methods |
---|---|---|---|
1 | Introduction to Toxicology: Definitions and Basic Concepts | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
2 | Toxicity Mechanisms and Factors Affecting Toxicity | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
3 | Toxicokinetic I: Absorption, Distribution and Elimination of Xenobiotics | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
4 | Toxicokinetic II: Biotransformation of xenobiotics | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
5 | Toksisite Testleri ve Risk değerlendirmesi | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
6 | Acute Poisoning Therapy and Antidote | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
7 | Specific Toxic Effects I: Genotoxicity, Mutagenicity, Carcinogenicity | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
8 | Mid-Term Exam | Lesson Repetition Subject Repetition An overview | Ölçme Yöntemleri: Yazılı Sınav |
9 | Specific Toxic Effects II: Reproductive and Developmental Toxicity | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
10 | Other Risks of Drug Use in Pregnancy and Teratogenicity | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
11 | ntroduction to Immunotoxicology and Allergic Reactions | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
12 | Genetic Polymorphism-Related Toxic Effects | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
13 | Toxic substances of natural origin | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
14 | Food additives and contaminants | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
15 | Environmental Toxicology and Disaster Toxicology | Reading the Related Section of the Textbook | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
16 | Term Exams | Lesson Repetition Subject Repetition An overview | Ölçme Yöntemleri: Yazılı Sınav |
17 | Term Exams | Lesson Repetition Subject Repetition An overview | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
Works | Number | Time (Hour) | Workload (Hour) |
---|---|---|---|
Course Related Works | |||
Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
Assesment Related Works | |||
Homeworks, Projects, Others | 0 | 0 | 0 |
Mid-term Exams (Written, Oral, etc.) | 1 | 6 | 6 |
Final Exam | 1 | 16 | 16 |
Total Workload (Hour) | 78 | ||
Total Workload / 25 (h) | 3,12 | ||
ECTS | 3 ECTS |