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Information
| Code | BT0084 |
| Name | Molecular metabolism of cancer |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator |
Course Goal / Objective
All students who take the course should acquire basic information about the molecular metabolism of cancer, learn the biotechnological uses of this information and follow the researches on this subject.
Course Content
Definitions related to cancer metabolism, complex structure of cancer cell, energy types, mitochondrial mutations, autophagy, microenvironment and the effect of pH on metabolism, hypoxic adaptation mechanisms, enzymes involved in metabolism and various energy pathways, current use and targeting of metabolism in cancer diagnosis treatment. What can be done, article review and presentation.
Course Precondition
To be a graduate of the Department of Molecular Biology and Genetics or to be successful by taking a Molecular Biology course at the M.L. and DR course stage (before taking this course).
Resources
Textbook of Cell Signaling in Cancer, Yazarlar: Roberts, Jacques Cell Signaling- Principles and Mechanisms. Yazarlar: Wandell Lim, Bruce Mayer, Tony Pawson Cell Signaling Biology – online tool http://www.cellsignallingbiology.co.uk/csb/
Notes
Textbook of Cell Signaling in Cancer, Yazarlar: Roberts, Jacques Cell Signaling- Principles and Mechanisms. Yazarlar: Wandell Lim, Bruce Mayer, Tony Pawson Cell Signaling Biology – online tool http://www.cellsignallingbiology.co.uk/csb/
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | In this course, students understand the metabolism of the cancer cell, the signals that affect the metabolism, and the existence of systems that can adapt itself in the presence of different conditions such as hypoxia. |
| LO02 | Gains knowledge of the systems that affect cancer cell metabolism and the principle of escape methods when the cell needs energy, by using interactive and research-based learning methods. |
| LO03 | Gain knowledge of the literature on the use of cancer metabolism in targeted therapies |
| LO04 | Learns the evaluation of scientific research on the subject and the presentation of the articles. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develop and deepen the current and advanced knowledge in the field with original thought and / or research at the level of expertise based on the qualifications of the graduate and reach the original definitions that will bring innovation to the field. | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Understands the interdisciplinary interaction of the field; it achieves original results using knowledge requiring expertise in analysis, synthesis and evaluation of new and complex ideas. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Evaluates, uses and transfers new information in the field with a systematic approach. | 5 |
| PLO04 | Beceriler - Bilişsel, Uygulamalı | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | 4 |
| PLO05 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Makes leadership in environments that require the analysis of original and interdisciplinary problems. | |
| PLO06 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | It extends the limits of knowledge in its field by publishing at least one scientific article in its field in national and / or international refereed journals and / or producing or interpreting an original work. | |
| PLO07 | Yetkinlikler - Öğrenme Yetkinliği | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | |
| PLO08 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | He / she defends his / her original opinions in discussing the subjects in his / her field and establishes an effective communication showing his / her competence in the field. | |
| PLO09 | Yetkinlikler - Alana Özgü Yetkinlik | Conducts scientific research in national and international scientific research groups. | |
| PLO10 | Yetkinlikler - Alana Özgü Yetkinlik | Establishes functional interaction by using strategic decision making processes in solving problems encountered in the field. | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Objectives and targets of the molecular metabolism of cancer course, discussing the course content and plan, students' expectations. Definitions related to metabolism. | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 2 | The complex structure of the malignant tumors and its adaptation to metabolic variability | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 3 | Energy metabolism and its regulation in tumor cells | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 4 | Autophagy and its relationship with tumor metabolism | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 5 | Hypoxia adaptation mechanisms in cancer – Hypoxia Inducible Transcription factors (HIF) | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 6 | Autophagic signaling pathways and its control | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 7 | HIF signaling pathway and functions of target genes | Ders notlarının okunması ve power point sunumu | Öğretim Yöntemleri: Soru-Cevap |
| 8 | Mid-term Exam | power point | Ölçme Yöntemleri: Ödev |
| 9 | Effects of pH changes and microenvironment on tumor metabolism | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 10 | Mechanism of mitochondrial mutations | Preliminary reading on mitochondrial mutations | Öğretim Yöntemleri: Soru-Cevap |
| 11 | Learning myc regulation and its relationship with cancer metabolism through an article | Pre-reading the article | Öğretim Yöntemleri: Soru-Cevap |
| 12 | Association of the pentose phosphate pathway with tumor metabolism | Study of the pentose phosphate pathway | Öğretim Yöntemleri: Soru-Cevap |
| 13 | Targeting tumor metabolism in cancer diagnosis and treatment | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 14 | Current Innovations to target tumor metabolism | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 15 | Article presentations on tumor metabolism | Reading the lecture notes and powerpoint presentation | Öğretim Yöntemleri: Soru-Cevap |
| 16 | Final Exam | Reading the lecture notes and powerpoint presentation | Ölçme Yöntemleri: Ödev |
| 17 | Final Exam | Reading the lecture notes and powerpoint presentation | Ölçme Yöntemleri: Yazılı Sınav, Ödev |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 2 | 6 | 12 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 150 | ||
| Total Workload / 25 (h) | 6,00 | ||
| ECTS | 6 ECTS | ||