TÜRKÇE
ENGLISH
Information
| Code | EFR505 |
| Name | In vivo and In vitro Drug Studies |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
1 |
Course Goal / Objective
It aims to provide the ability to distinguish differences between in vitro and in vivo studies.
Course Content
Basic information about experimental pharmacology and general methodology , In vitro and in vivo study methods and recording systems
Course Precondition
None
Resources
1- Kayaalp S. Oğuz. Akılcı Tedavi Yönünden Tıbbi Farmakoloji 1ve2 cilt,Pelikan Yayınları,2019. 2- Jann Hau, Gerald L Van Hoosier, Animal models in pharmacology and toxicology. In: Handbook of laboratory animal science. 2nd edition CRC Press, 2003. 3-Bökesoy T.Arda. Isolated smooth muscle preparations, Turkish Pharmacology Society Publications,1993. 4-Current Literatures.
Notes
Büyüknacar HS, Lecture notes (2023)
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Lists laboratory materials to be used in experimental studies. |
| LO02 | Explains the methods used in experimental research. |
| LO03 | Explains in vitro and in vivo research methods. |
| LO04 | Detects problems that may arise in experiments. |
| LO05 | Interprets the results of the experimental data. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 2 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | 4 |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 4 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Explain a relationship between the effects, mechanisms of action and drug interactions of drugs. | |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | 4 |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | 3 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. | 5 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Explaining the Importance of the Course, Its Operation and Evaluation Method to the Student. Explaining the Importance of the Course | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 2 | Explanation of Uses of Laboratory Materials | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Gösteri |
| 3 | Animal Models Used in Experimental Research: Hypertension, Cystitis, Diabetes | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Preclinical Experimental Studies: In vitro organ bath experiments | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Deney / Laboratuvar |
| 5 | In Vitro Organ Bath Assembly and Recording Systems (Isometric and Isotonic Transducer) | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Deney / Laboratuvar |
| 6 | What are the physiological solutions used in in vitro organ bath experiments and their importance | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 7 | Dose Calculation in In Vitro Studies | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Subject repetition | Ölçme Yöntemleri: Sözlü Sınav, Performans Değerlendirmesi |
| 9 | Drug Administration to Experimental Animals | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Deney / Laboratuvar |
| 10 | In Vivo Study Methods, Drug Administration Routes and Calculation of the Drug Dose to be administered | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Calculation of Drug Dose to be Administered In Vivo | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | In Vivo Registration System | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | In Vivo Experiment Model-1 | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 14 | In Vivo Experiment Model-2 | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 15 | Analysis and Interpretation of Data | Reading related books and literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 16 | Term Exam | General Review | Ölçme Yöntemleri: Ödev, Performans Değerlendirmesi |
| 17 | Term Exams | General Review | Ölçme Yöntemleri: Ödev, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 7 | 7 |
| Final Exam | 1 | 18 | 18 |
| Total Workload (Hour) | 109 | ||
| Total Workload / 25 (h) | 4,36 | ||
| ECTS | 4 ECTS | ||