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Information
| Code | BİO645 |
| Name | Gene - Genome and Proteome |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
Form the necessary background for understanding properties, differences of gene and genome structure and understanding the relationship with diseases.
Course Content
Gene structure, active genes, evolution of genes with introns, Evolution and Exons, Domain, Species complexity and Gene number, Essential gene number and its importance. The relationship between protein size and genome and complexity, genome structure, genome, transcriptome, proteome and protein protein interaction concepts, genomic size, human genome, genomics and proteomics, protein properties and proteomics, Why Proteome, The relationship between homology and protein structure and function, applications in proteomics and medicine, proteome studies and stages, proteome techniques,
Course Precondition
To have taken BIO-501 and BIO-502 Medical Genetics Courses
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Notes
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows the terms-ending in -omics, such as genomics, proteomics or metabolomics |
| LO02 | Is able to understand connections between genomics, proteomics and metabolomics |
| LO03 | Knows the projects done in the field of omics |
| LO04 | Knows the connections between Omics and complex diseases |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | 1 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | 2 |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | 2 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | 1 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | 1 |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 2 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Gene structure | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 2 | Active genes, evolution of genes with introns | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri, Alıştırma ve Uygulama, Soru-Cevap |
| 3 | importance of gene junction | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri, Soru-Cevap |
| 4 | Evolution and Exons, Domain | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri, Soru-Cevap |
| 5 | Species complexity and Gene number | Slide preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 6 | Relationship of species complexity with gene number and genome size | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 7 | Essential gene number and its importance | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 8 | Mid-Term Exam | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | The relationship between protein size and genome and complexity | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 10 | Genome structure, genome | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 11 | Transcriptome, proteom and protein protein interaction concepts | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 12 | Genomic size, human genome, genomics and proteomics | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 13 | Protein properties and proteomics, Why Proteom | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 14 | The relationship between homology and protein structure and function | Slide preparation | Öğretim Yöntemleri: Tartışma |
| 15 | Applications in proteomics and medicine, proteome studies and stages, proteome techniques | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma, Gösteri |
| 16 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 3 | 12 | 36 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 126 | ||
| Total Workload / 25 (h) | 5,04 | ||
| ECTS | 5 ECTS | ||