BİO648 Immunogenetics

5 ECTS - 3-0 Duration (T+A)- . Semester- 3 National Credit

Information

Code BİO648
Name Immunogenetics
Term 2024-2025 Academic Year
Semester . Semester
Duration (T+A) 3-0 (T-A) (17 Week)
ECTS 5 ECTS
National Credit 3 National Credit
Teaching Language Türkçe
Level Doktora Dersi
Type Normal
Mode of study Yüz Yüze Öğretim
Catalog Information Coordinator Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP


Course Goal / Objective

The student who completed this course; taking part in the Immunology; Antibody recognizes the properties of T Cell Receptor and MHC system, genetic mechanisms that provide diversity and importance of antigen processing and presentation. know the general information about the immune system, cells and organs, learn the mechanisms of action of natural and acquired immunity. It has information about the molecular basis for the processing of antigens entering the body and presentation to the immune system. In light of this information enables us to analyze new and complex ideas , develop up-to-date information in immunology, original thought and research and expertise.

Course Content

Introduction to immune system, history and evolution, Antigen and Tolerance concepts, Molecules and systems involved in immunology, Genetic mechanisms that provide antibody differentiation, T cell receptor differentiation and development mechanisms, MHC gene and its function, Antigen processing and presentation, Immune response genes and MHC association, Hereditary immune system diseases, important and diversty of TLR receptor, Tumor immunology, immunotherapy

Course Precondition

Gene Genome Proteome and Aging Biology and Genetics courses must be taken

Resources

1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020

Notes

1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020


Course Learning Outcomes

Order Course Learning Outcomes
LO01 Knows he importance of antibody, T cell receptor and MHC system with the role of immune recognition
LO02 Knows the importance of genetic mechanisms that provide diversity, antigen processing and presentation
LO03 Having knowledge about mechanisms of antibody formation, genetic mechanisms that provide TCR diversity.
LO04 To understand MHC gene structure and its importance.
LO05 To understand the relationship between MHC gene polymorphism and antigen presentation
LO06 To understand general information about cells and organs of immune system.
LO07 Understand the genetic link between the MHC system and autoimmunity
LO08 Having knowledge about the relationship between protein processing and folding and MHC presentation.
LO09 To understand the relationship between MHC system and tumor immunology


Relation with Program Learning Outcome

Order Type Program Learning Outcomes Level
PLO01 Bilgi - Kuramsal, Olgusal To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes 3
PLO02 Bilgi - Kuramsal, Olgusal To have information about genetic diseases
PLO03 Bilgi - Kuramsal, Olgusal To have knowledge of Molecular Cell Biology 5
PLO04 Bilgi - Kuramsal, Olgusal To apply fluorescence in-situ hybridization (FISH) technique 4
PLO05 Bilgi - Kuramsal, Olgusal To make DNA isolation and PCR of all kinds of tissue
PLO06 Bilgi - Kuramsal, Olgusal To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) 3
PLO07 Bilgi - Kuramsal, Olgusal To do cytogenetic analysis by recognizing human chromosomes separately 4
PLO08 Bilgi - Kuramsal, Olgusal To make QF-PCR and to interpret the results 3
PLO09 Bilgi - Kuramsal, Olgusal To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties
PLO10 Bilgi - Kuramsal, Olgusal To write and implement a research project on his/her own 2
PLO11 Bilgi - Kuramsal, Olgusal To write an article by collecting the information obtained at the end of the research 2
PLO12 Yetkinlikler - Öğrenme Yetkinliği To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level 2


Week Plan

Week Topic Preparation Methods
1 Introduction to immune system, history and evolution preliminary research on the subject from source books Öğretim Yöntemleri:
Tartışma, Anlatım
2 Antigen and Tolerance concepts preliminary research on the subject from source books Öğretim Yöntemleri:
Tartışma
3 Molecules and systems involved in immunology preliminary research on the subject from source books Öğretim Yöntemleri:
Tartışma
4 Genetic mechanisms that provide antibody differentiation preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım, Tartışma
5 T cell receptor differentiation and development mechanisms preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım, Tartışma
6 MHC gene and its function preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım
7 Antigen processing and presentation preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım
8 Mid-Term Exam Evaluation-Examination Ölçme Yöntemleri:
Sözlü Sınav
9 Immune response genes and MHC associatio preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım, Tartışma
10 TLR receptor diversity and its importance preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım
11 Hereditary immune system disease preliminary research on the subject from source books Öğretim Yöntemleri:
Tartışma
12 Defense against infectious agents preliminary research on the subject from source books Öğretim Yöntemleri:
Tartışma, Soru-Cevap
13 Immunlogic tolerance and autoimmunity preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım
14 Tumor immunology preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım
15 immunotherapy preliminary research on the subject from source books Öğretim Yöntemleri:
Anlatım, Tartışma
16 Term Exams Evaluation-Examination Ölçme Yöntemleri:
Ödev, Sözlü Sınav
17 Term Exams Evaluation-Examination Ölçme Yöntemleri:
Ödev, Sözlü Sınav


Student Workload - ECTS

Works Number Time (Hour) Workload (Hour)
Course Related Works
Class Time (Exam weeks are excluded) 14 3 42
Out of Class Study (Preliminary Work, Practice) 14 3 42
Assesment Related Works
Homeworks, Projects, Others 4 10 40
Mid-term Exams (Written, Oral, etc.) 1 3 3
Final Exam 1 3 3
Total Workload (Hour) 130
Total Workload / 25 (h) 5,20
ECTS 5 ECTS

Update Time: 26.09.2024 12:01