TÜRKÇE
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Information
| Code | BİO647 |
| Name | Genomics and Farmacovijilans |
| Term | 2024-2025 Academic Year |
| Semester | . Semester |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 5 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. HÜSNÜ ÜMİT LÜLEYAP |
Course Goal / Objective
To gain perspective on the relationship of the most important goals of today's medicine with the genome structure such as individual drug, rational drug and drug side effects.
Course Content
Types of mutations, Differences between polymorphism and mutation, The importance of short sequence repeats (SSR) and single nucleotide differences (SNPs) in the genome structure, Gene concept. Genomic and functional genomics, Genotypes and different drug effects, Rational drug use, Pharmacovigilance, Molecular approaches in drug design
Course Precondition
Gene, Genome and proteome courses and Epigenetics courses must be taken
Resources
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Notes
1-Moleküler Genetiğin Esasları, Ümit Lüleyap Akademisyen Kitabevi 2. baskı. 2020 2- The Biology of Cancer Robert A, Weinberg 2. Edition Garland Sciences. 3-The Cell. A Molecular Approach, G:M. Cooper Sewenth Edition Snauer
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Knows the concept of pharmacovigilance and its relationship with genetics |
| LO02 | Knows the personalized medicine and treatment concept. |
| LO03 | Knows the concept of polymorphism, enzyme kinetics and the interaction between drug metabolism |
| LO04 | Knows the relationship between detoxification, biotransformation, phase1 and phase2 change and transformation concepts and genetics |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To make and interpret Medical Genetics, Molecular Genetics and Cytogenetic analyzes | 4 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To have information about genetic diseases | 4 |
| PLO03 | Bilgi - Kuramsal, Olgusal | To have knowledge of Molecular Cell Biology | |
| PLO04 | Bilgi - Kuramsal, Olgusal | To apply fluorescence in-situ hybridization (FISH) technique | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make DNA isolation and PCR of all kinds of tissue | 3 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To make cell culture of all kinds of tissue (blood, amniotic fluid, chorionic villus biopsy) | |
| PLO07 | Bilgi - Kuramsal, Olgusal | To do cytogenetic analysis by recognizing human chromosomes separately | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | To make QF-PCR and to interpret the results | |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have the knowledge and skills to teach Medical Biology and Genetics Courses in Medical Faculties | 2 |
| PLO10 | Bilgi - Kuramsal, Olgusal | To write and implement a research project on his/her own | |
| PLO11 | Bilgi - Kuramsal, Olgusal | To write an article by collecting the information obtained at the end of the research | 2 |
| PLO12 | Yetkinlikler - Öğrenme Yetkinliği | To organize laboratory courses of Medical Biology and Genetics courses at undergraduate level | 2 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Types of mutations | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 2 | importance of spontaneous mutation | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 3 | Differences between polymorphism and mutation | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 4 | Types of mutation and polymorphisms | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 5 | Gene concept, The importance of short sequence repeats (SSR) and single nucleotide differences (SNPs) in the genome structure, | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 6 | importance of genome sequences in pharmacogenetics | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 7 | Genomic and functional genomics | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 8 | Mid-Term Exam | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Pharmacogenetic pespectives of OMIC | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 10 | Genotypes and different drug effects | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 11 | Rational drug usage | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 12 | Pharmacovigilance | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 13 | drug design | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 14 | Molecular approaches in drug design | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 15 | Problems of drug design | Slide preparation | Öğretim Yöntemleri: Anlatım, Tartışma |
| 16 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Preparation of multiple-choice questions | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 3 | 42 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 4 | 8 | 32 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 3 | 3 |
| Final Exam | 1 | 3 | 3 |
| Total Workload (Hour) | 122 | ||
| Total Workload / 25 (h) | 4,88 | ||
| ECTS | 5 ECTS | ||