TÜRKÇE
ENGLISH
Information
| Code | BFZ621 |
| Name | Ion Channels and Channelopathies-Molecular Approach |
| Term | 2024-2025 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
Doç. Dr. ÇAĞIL COŞKUN
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
Providing knowledge to conduct molecular-level studies on the path to treating ion channel diseases
Course Content
Ion Channels, Evolution and Diversity of Ion Channels - Phylogenetic Analyses, Voltage-Gated Sodium Channel, Voltage-Gated Sodium Channel Diseases, Voltage-Gated Potassium Channel and Diseases, Voltage-Gated Calcium Channel and Diseases, Determination of Primary Gene Sequences of Ion Channels, Structural Analyses of Ion Channels, Genetic Analyses of Ion Channels, Functional Analyses of Ion Channels, Regulation and Modulation of Genes Encoding Channel Proteins, Therapeutic Targets and Strategies, Molecular Genetic Approaches to the Treatment of Channelopathies I, Molecular Genetic Approaches to the Treatment of Channelopathies II
Course Precondition
none
Resources
Kandel, E.R. (2013). Principles of Neural Science (5.bs). New York:McGraw-Hill Zheng, J.; Trudeau, M.C. (2015). Handbook of Ion Channel. Taylor&Francis
Notes
Ashcroft, F.M. (1999). Ion Channels and Disease. Aca
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Gains detailed knowledge about ion channels |
| LO02 | Learns the genetic basis of ion channels and their functional units. |
| LO03 | Understands the sources of genetic-level alterations of channelopathies. |
| LO04 | Learns the pathway and methodologies to be followed for uncovering the genetic, structural, and functional characteristics of ion channels, enabling the development of model organisms and therapeutic strategies on the path to treating channelopathies. |
| LO05 | Learns molecular genetic approaches for the diagnosis and treatment of ion channel diseases. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | To learn the basic information about the field | 3 |
| PLO02 | Bilgi - Kuramsal, Olgusal | To be able to establish experimental work in laboratory | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | To prepare a project proposal by itself | |
| PLO04 | Bilgi - Kuramsal, Olgusal | To plan an experimental research | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | To make a report as a result of the research | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | To be able to interpret research findings | 4 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Having analytical thinking mechanism related to the field Accessing reliable information Creating and writing a research project Study and research based on ethic values | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Ability to transfer the theoretical knowledge to the audience in a systematic way | 5 |
| PLO09 | Bilgi - Kuramsal, Olgusal | To have scientific thought systematic about the profession | 5 |
| PLO10 | Bilgi - Kuramsal, Olgusal | Kendi başına bir proje önerisi hazırlayabilmek | 4 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Ion Channels | Reading the relevant section from the sources | |
| 2 | Evolution and Diversity of Ion Channels - Phylogenetic Analyses | Reading the relevant section from the sources | |
| 3 | Voltage Gated Sodium Channels | Reading the relevant section from the sources | |
| 4 | Voltage-Gated Sodium Channel Diseases | Reading the relevant section from the sources | |
| 5 | Voltage-Gated Potassium Channels and Diseases | Reading the relevant section from the sources | |
| 6 | Voltage-Gated Calcium Channels and Diseases | Reading the relevant section from the sources | |
| 7 | Determination of the Primary Gene Sequences of Ion Channels | Reading the relevant section from the sources | |
| 8 | Mid-Term Exam | ||
| 9 | Structural Analyses of Ion Channels | Reading the relevant section from the sources | |
| 10 | Genetic Analyses of Ion Channels | Reading the relevant section from the sources | |
| 11 | Functional Analyses of Ion Channels | Reading the relevant section from the sources | |
| 12 | Regulation and Modulation of Genes Encoding Channel Proteins | Reading the relevant section from the sources | |
| 13 | Therapeutic Targets and Strategies | Literature Review and Reading | |
| 14 | Molecular Genetic Approaches to the Treatment of Channelopathies I | Literature Review and Reading | |
| 15 | Molecular Genetic Approaches to the Treatment of Channelopathies II | Literature Review and Reading | |
| 16 | Term Exams | ||
| 17 | Term Exams |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 1 | 14 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 16 | 16 |
| Total Workload (Hour) | 80 | ||
| Total Workload / 25 (h) | 3,20 | ||
| ECTS | 3 ECTS | ||