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Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| ANATOMY (MEDICINE) (PhD) | |
| Code | ANA608 |
| Name | Experimental Spinal Cord Injury Models and Nerve Repair |
| Term | 2025-2026 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. HÜSEYİN ERDEM |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
This course aims to theoretically examine experimental spinal cord injury (SCI) models and nerve repair mechanisms. It covers the anatomical and histological effects of spinal cord trauma, types of experimental models (transection, crush, contusion, etc.), motor function recovery, regenerative treatments, and clinical implications. The course also focuses on injury mechanisms, fundamental principles of nerve regeneration, the clinical translation process, and the evaluation of current therapeutic strategies.
Course Content
This course analyzes the anatomical, histological, and physiological effects of experimental spinal cord injury (SCI) models and addresses nerve repair processes from a theoretical perspective. It discusses how spinal cord injuries are studied in experimental animal models, as well as innovative approaches such as biological and pharmacological agents supporting nerve regeneration, tissue engineering, and gene therapy. By the end of the course, students will evaluate how findings from experimental models can be translated into clinical applications.
Course Precondition
There are no prerequisites for this course.
Resources
1. Current articles and online resources 2. Dere Anatomi Atlası ve Ders Kitabı 3. Dere Atlaslı Nöroanatomi ve Fonksiyonel Nöroloji
Notes
Additional readings will be provided during the course.
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Describes the anatomy of the spinal cord and the changes that occur as a result of injury. |
| LO02 | Classifies and compares experimental models used for spinal cord injuries. |
| LO03 | Explains the cellular and histopathological effects of spinal cord injury. |
| LO04 | Evaluates the mechanisms of biological and pharmacological agents involved in spinal cord regeneration. |
| LO05 | Analyzes how experimental findings are translated into clinical neurological rehabilitation processes. |
| LO06 | Discusses regenerative approaches such as gene therapy, stem cell therapy, and biomaterials. |
| LO07 | Conducts literature reviews and follows academic developments in experimental nerve regeneration. |
| LO08 | Critically evaluates scientific studies related to spinal cord injuries. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Develops and deepens the current and advanced level knowledge of anatomy via unique thoughts or researches at a level of proficiency, find out original definitions that will bring innovation in the field of anatomy. | 2 |
| PLO02 | Bilgi - Kuramsal, Olgusal | Comprehends the interdisciplinary interactions related to anatomy; analyze, synthesize and evaluates original and new thoughts. | 3 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Explains the usage of tool, devices and instruments requiered for knowledge and technologies about anatomy and related disciplines. | |
| PLO04 | Bilgi - Kuramsal, Olgusal | Explains importance of ethical rules and principles for individual and societies. | |
| PLO05 | Bilgi - Kuramsal, Olgusal | Defines frequently used statistical methods in anatomy and related disciplines. | |
| PLO06 | Bilgi - Kuramsal, Olgusal | Evaluates and uses new knowlegde about anatomy via systematic approach. | |
| PLO07 | Bilgi - Kuramsal, Olgusal | Develops a new thoughts, method and designment/application which is brings innovation in anatomy or implements a known thoughts, method and designment/application in different fields, investigates, comprehends, designs, adapts, implements an original topic. | 2 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Writes the report of his reaearch which he/she participated and publishes/presents in peer-reviewed national/international journals or scientific meeting. | |
| PLO09 | Bilgi - Kuramsal, Olgusal | Makes an critical analysis, synthesis and evaluation of new and analytical thoughts. | |
| PLO10 | Bilgi - Kuramsal, Olgusal | Uses scientific research methods at an advanced level in their studies. | |
| PLO11 | Bilgi - Kuramsal, Olgusal | Makes necessary investigations by using tool, devices and instruments required for knowledge and technologies about anatomy and related disciplines at an advanced level, develops a new and creative solutions for problems. | 2 |
| PLO12 | Bilgi - Kuramsal, Olgusal | Leads the solutions of problems regarding anatomy and related disciplines. | |
| PLO13 | Bilgi - Kuramsal, Olgusal | Performs the statistical analysis to evaulate scientific paper, publishes/presents in peer-reviewed national/international journals. | |
| PLO14 | Beceriler - Bilişsel, Uygulamalı | Develops the evidence based new methods and thoughts about anatomy by utilizing mechanisms of creative, critical thinking, problem solving and decision-making | |
| PLO15 | Beceriler - Bilişsel, Uygulamalı | Implements vocational development and life-long learning principles related to anatomy field in his/her studies. | 2 |
| PLO16 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Communicates effectively and competently with specialists about the anatomy and related fields during discussion while defending original thoughts of his/her | |
| PLO17 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Discusses and makes visually, written and orally communication by using the C1 level for Common European Framework of Reference for Languages at an advanced level. | |
| PLO18 | Yetkinlikler - Öğrenme Yetkinliği | Communicates functionally by using mechanisms of ethical and strategic desicion for solving encountered problems, contributes to be and maintain process of information society by presenting scientific, technological, social and cultural advancements related to anatomy. | |
| PLO19 | Yetkinlikler - Öğrenme Yetkinliği | Chooses accurately statistical methods, implements, discusses accurately for his/her studies anatomy and related disciplines and analyzes-synthesize within the scope of ethical rules. | |
| PLO20 | Yetkinlikler - Öğrenme Yetkinliği | Uses the current developments and knowledge regar ding anatomy field for the benefits of the children, families, national values and societies in accordance with the facts of country. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Anatomy and physiology of the spinal cord | Basic neuroanatomy resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Spinal cord injuries: Classification and pathophysiology | Current articles, case reports | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Experimental spinal cord injury models: Transection, crush, contusion | Experimental neuroanatomy sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Cellular changes after injury: Glial scar, neuronal degeneration | Nervous system histology sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Motor function loss and experimental evaluation methods | Functional neuroanatomy sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Nerve regeneration: Mechanisms and inhibitory factors | Nerve repair literature review | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Biomaterials, stem cell, and gene therapy approaches | Regenerative medicine sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | Exam preparations | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
| 9 | Pharmacological treatments for spinal cord injury | Current pharmacology articles | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | Clinical cases and translational nerve regeneration | Clinical neuroanatomy resources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Rehabilitation strategies in spinal cord injury | Neurological rehabilitation sources | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Current literature review and experimental nerve regeneration studies | Scientific database search | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Student presentations: Experimental spinal cord injury and nerve repair | Project preparation | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 14 | Discussion of personal experiences | All topics | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 15 | General review and case analyses | All topics | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 16 | Term Exams | Exam preparations | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
| 17 | Term Exams | Exam preparations | Ölçme Yöntemleri: Ödev, Sözlü Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 4 | 56 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 1 | 15 | 15 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 10 | 10 |
| Final Exam | 1 | 20 | 20 |
| Total Workload (Hour) | 143 | ||
| Total Workload / 25 (h) | 5,72 | ||
| ECTS | 6 ECTS | ||