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Information
| Unit | INSTITUTE OF NATURAL AND APPLIED SCIENCES |
| BIOLOGY (PhD) | |
| Code | BY772 |
| Name | Extracellular Matrix in Disease and Health |
| Term | 2025-2026 Academic Year |
| Term | Spring |
| Duration (T+A) | 3-0 (T-A) (17 Week) |
| ECTS | 6 ECTS |
| National Credit | 3 National Credit |
| Teaching Language | Türkçe |
| Level | Doktora Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Prof. Dr. SADIK DİNÇER |
| Course Instructor |
Dr. Öğr. Üyesi ÖZGECAN KAYALAR
(Bahar)
(A Group)
(Ins. in Charge)
|
Course Goal / Objective
To learn the structural elements of the extracellular matrix in detail. To understand the functional roles of matrix-cellular proteins and the basal membrane. To grasp the mechanisms of extracellular matrix remodeling and the functionality of these processes. To learn how matrix-modifying enzymes are regulated and function. To analyze critical pathological processes involving the extracellular matrix. To learn about the use of extracellular modifications in creating three-dimensional disease models. To learn the methods used in extracellular matrix studies.
Course Content
Introduction to the extracellular matrix, structure and function of collagen and elastin, adhesive glycoproteins, matrix proteoglycans, basement membrane, extracellular matrix remodeling and recycle, matrix metalloproteinases; inhibitors, activators and signaling, wound healing and the extracellular matrix, fibrosis and the extracellular matrix, tumor invasion and metastasis. Investigation of three-dimensional disease models created with extracellular matrix modifications, methods used in extracellular matrix studies.
Course Precondition
None
Resources
Current publications
Notes
1-Mecham, R. P. (ed.) The Extracellular Matrix: an Overview (Springer, 2011). 2-Hynes, R. O. & Yamada, K. M. (eds) Extracellular Matrix Biology (Cold Spring Harbor Lab. Press, 2012). 3. Current literature on the subject
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | The extracellular matrix provides information about the structure and function of collagen and elastin. |
| LO02 | Students will gain knowledge about adhesive glycoproteins and matrix proteoglycans. |
| LO03 | They learn about matrix proteins and enzymes. |
| LO04 | Students gain knowledge about the basal membrane, matrix metalloproteinases, extracellular matrix remodeling, and turnover. |
| LO05 | Students learn about wound healing and the relationship between the extracellular matrix. |
| LO06 | They will gain knowledge about fibrosis and the extracellular matrix. |
| LO07 | The role of the extracellular matrix during tumor invasion and metastasis is learned. |
| LO08 | Students gain knowledge about extracellular matrix modifications in the creation of three-dimensional disease models. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Based on the qualifications of the graduate, it develops and deepens the current and advanced knowledge in the field with original thought and / or research at the level of expertise and reaches the original definitions that will bring innovation to the field. | |
| PLO02 | Bilgi - Kuramsal, Olgusal | Evaluates, uses and transfers new information in the field with a systematic approach. | 2 |
| PLO03 | Bilgi - Kuramsal, Olgusal | Develops a new idea, method, design and / or application that brings innovation to the field, or applies a known idea, method, design and / or application to a different field, researches, comprehends, designs and applies an original topic. | 3 |
| PLO04 | Bilgi - Kuramsal, Olgusal | Gains high level skills in using research methods in the field studies. | 3 |
| PLO05 | Bilgi - Kuramsal, Olgusal | Makes critical analysis, synthesis and evaluation of new and complex thoughts. | 4 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Extends the boundaries of knowledge in the field by publishing at least one scientific paper in national and / or international refereed journals and / or producing or interpreting an original work. | 2 |
| PLO07 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Examines and develops the social relations and the norms that direct these relations from a critical point of view. | |
| PLO08 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Defends his / her original opinions in discussing the subjects in his / her field with experts, and establishes an effective communication showing his / her competence in his / her field. | 3 |
| PLO09 | Yetkinlikler - Öğrenme Yetkinliği | Introducing scientific, technological, social or cultural advances in the field; It contributes to the process of being a society of knowledge and sustaining it. | |
| PLO10 | Yetkinlikler - Öğrenme Yetkinliği | It contributes to the solution of social, scientific, cultural and ethical problems encountered in the field and supports the development of these values. | |
| PLO11 | Beceriler - Bilişsel, Uygulamalı | Develops new ideas and methods related to the field by using high level mental processes such as creative and critical thinking, problem solving and decision making. | 3 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to the extracellular matrix | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 2 | Structure and function of collagen and elastin | Reading current lecture notes and related articles, internet research | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 3 | Adhesive glycoproteins | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 4 | Matrix proteoglycans | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 5 | Matrix cellular proteins and enzymes | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 6 | Basal membrane | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 7 | Extracellular matrix remodeling and turnover | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 8 | Mid-Term Exam | general review | Ölçme Yöntemleri: Sözlü Sınav, Performans Değerlendirmesi, Ödev |
| 9 | Matrix Metalloproteinases | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 10 | The role of other matrix-modifying enzymes and cofactors. | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 11 | Wound healing and extracellular matrix | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 12 | Fibrosis and extracellular matrix | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap |
| 13 | Tumor invasion and metastasis | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Soru-Cevap, Anlatım |
| 14 | Extracellular matrix modifications and 3D culture models | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 15 | Methods used in extracellular matrix studies | Reading current lecture notes and related articles, internet research. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 16 | Term Exams | general review | Ölçme Yöntemleri: Sözlü Sınav, Yazılı Sınav, Performans Değerlendirmesi |
| 17 | Term Exams | oral/writing exam | Ölçme Yöntemleri: Yazılı Sınav, Sözlü Sınav, Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 3 | 42 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 5 | 70 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 15 | 15 |
| Final Exam | 1 | 30 | 30 |
| Total Workload (Hour) | 157 | ||
| Total Workload / 25 (h) | 6,28 | ||
| ECTS | 6 ECTS | ||