TÜRKÇE
ENGLISH
Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| PEDIATRIC ONCOLOGY (MASTER) (WITH THESIS) | |
| Code | PEDO522 |
| Name | Molecular Basis of Childhood Cancers |
| Term | 2026-2027 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 4-2 (T-A) (17 Week) |
| ECTS | 4 ECTS |
| National Credit | 4 National Credit |
| Teaching Language | Türkçe |
| Level | Yüksek Lisans Dersi |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
Identifying genetic factors—including germline and somatic mutations, epigenetic, and molecular features—and defining risk categories in pediatric cancers
Course Content
Molecular basics of childhood cancers
Course Precondition
Should know basic pathophysiology of cancer, genetic and environmental factors
Resources
Principles and practice of Pediatric Oncology, Pizzo & Poplack, editors: Drs. Susan M. Blaney, Peter C. Adamson, and Lee J. H, 9th ed.,2025
Notes
Online sources, journals
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Defines the epidemiology of childhood cancers |
| LO02 | Lists the etiology of pediatric cancers |
| LO03 | Lists the genetic factors in pediatric cancers |
| LO04 | Lists the molecular and epigentic factors in pediatric cancers |
| LO05 | Defines the patient's risk stratification based on molecular and genetic data |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | - | They gain expertise in donor selection. | |
| PLO02 | - | During the stem cell transplantation process, the most suitable graft is selected. | 1 |
| PLO03 | - | It lists the characteristics of donors according to the type of stem cell transplant. | 1 |
| PLO04 | - | It explains the concepts of haploidentical and allogeneic transplantation. | 1 |
| PLO05 | - | It lists the principles for collecting stem cells from cord blood. | |
| PLO06 | - | This describes the steps involved in collecting CD34 cells from peripheral blood. | |
| PLO07 | - | It describes the necessary conditions for collecting stem cells from bone marrow. | 1 |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Epidemiology of pediatric cancers | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 2 | Etiology of pediatric cancers | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 3 | Genetic factors | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 4 | Germline mutations | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 5 | Somatic mutations | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 6 | Visiting molecular genetic lab | Reading from the resources | Öğretim Yöntemleri: Alıştırma ve Uygulama |
| 7 | Pediatric Oncology ward visit | Reading from the resources | Öğretim Yöntemleri: Gösteri |
| 8 | Mid-Term Exam | lecture notes and recommended resources | Ölçme Yöntemleri: Performans Değerlendirmesi |
| 9 | Epigenetic changes | lecture notes and recommended resources | Öğretim Yöntemleri: Anlatım |
| 10 | DNA methylation | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 11 | chromatin remodeling | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 12 | Fusion genes and gene expression profiling | Reading from the resources | Öğretim Yöntemleri: Anlatım |
| 13 | Risk stratification of pediatric cancers based on molecular and genetic data | Reading from the resources | Öğretim Yöntemleri: Alıştırma ve Uygulama |
| 14 | Molecular genetic lab visit | Reading from the resources | Öğretim Yöntemleri: Alıştırma ve Uygulama |
| 15 | Molecular pathology lab visit | Reading from the resources | Öğretim Yöntemleri: Gösterip Yaptırma |
| 16 | Term Exams | lecture notes and recommended resources | Ölçme Yöntemleri: Performans Değerlendirmesi |
| 17 | Term Exams | lecture notes and recommended resources | Ölçme Yöntemleri: Performans Değerlendirmesi |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 8 | 7 | 56 |
| Out of Class Study (Preliminary Work, Practice) | 2 | 2 | 4 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 6 | 6 | 36 |
| Mid-term Exams (Written, Oral, etc.) | 2 | 2 | 4 |
| Final Exam | 1 | 1 | 1 |
| Total Workload (Hour) | 101 | ||
| Total Workload / 25 (h) | 4,04 | ||
| ECTS | 4 ECTS | ||