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Information
| Unit | INSTITUTE OF MEDICAL SCIENCES |
| PHARMACOLOGY (MASTER) (WITH THESIS) | |
| Code | EFR523 |
| Name | Individualized Pharmacotherapy |
| Term | 2026-2027 Academic Year |
| Term | Fall and Spring |
| Duration (T+A) | 2-0 (T-A) (17 Week) |
| ECTS | 3 ECTS |
| National Credit | 2 National Credit |
| Teaching Language | Türkçe |
| Level | Belirsiz |
| Type | Normal |
| Mode of study | Yüz Yüze Öğretim |
| Catalog Information Coordinator | Doç. Dr. Nursel SÜRMELİOĞLU |
| Course Instructor |
The current term course schedule has not been prepared yet.
|
Course Goal / Objective
The aim of this course is to teach the basic principles of individualized pharmacotherapy and to provide knowledge and skills for evaluating and optimizing drug therapy based on pharmacokinetic, pharmacodynamic, pharmacogenetic and clinical data according to individual patient characteristics.
Course Content
This course covers the fundamental concepts of individualized pharmacotherapy, including pharmacokinetic and pharmacodynamic variability, therapeutic drug monitoring, pharmacogenetic applications, management of drug therapy in special patient populations, drug interactions, dose individualization strategies and clinical decision-making processes through case-based discussions.
Course Precondition
None
Resources
Roger Walker, Cate Whittlesea, Karen Clancy. Clinical Pharmacy and Therapeutics • Oğuz Kayaalp. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji
Notes
UpToDate® • Lexicomp® Drug Information Handbook • Micromedex® • CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines • Current national and international clinical practice guidelines • Current scientific articles in the fields of individualized pharmacotherapy, therapeutic drug monitoring, and pharmacogenetics
Course Learning Outcomes
| Order | Course Learning Outcomes |
|---|---|
| LO01 | Ability to evaluate drug treatment according to individual patient characteristics. |
| LO02 | Ability to interpret pharmacokinetic and pharmacodynamic variables in clinical applications. |
| LO03 | Ability to apply therapeutic drug monitoring principles to individualized pharmacotherapy. |
| LO04 | To be able to evaluate the importance of pharmacogenetic approaches in individualized treatment. |
| LO05 | Developing clinical decision-making skills through case-based discussions. |
Relation with Program Learning Outcome
| Order | Type | Program Learning Outcomes | Level |
|---|---|---|---|
| PLO01 | Bilgi - Kuramsal, Olgusal | Explain the mechanisms of action of drugs, their pharmacokinetic and pharmacodynamic effects. | 4 |
| PLO02 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Acts in accordance with ethical and legal principles in the field of pharmacology. | 2 |
| PLO03 | Beceriler - Bilişsel, Uygulamalı | Can project and conduct research in the field of pharmacology and analyze and interpret data. | |
| PLO04 | Yetkinlikler - Alana Özgü Yetkinlik | It plays an active role in rational drug use and provides counseling to the patient for the correct use of the drug. | 3 |
| PLO05 | Yetkinlikler - İletişim ve Sosyal Yetkinlik | Can convey the current developments or studies in the field of pharmacology verbally or in writing. | 3 |
| PLO06 | Bilgi - Kuramsal, Olgusal | Follows scientific literature and current developments in the field of pharmacology. | 2 |
| PLO07 | Bilgi - Kuramsal, Olgusal | Explain a relationship between the effects, mechanisms of action and drug interactions of drugs. | 4 |
| PLO08 | Bilgi - Kuramsal, Olgusal | Explain the physiopathology of various diseases and evalue the drugs used in the treatment of these diseases. | |
| PLO09 | Beceriler - Bilişsel, Uygulamalı | Knows and uses good laboratory practices. | |
| PLO10 | Beceriler - Bilişsel, Uygulamalı | Uses the theoretical and applied knowledge gained in the field of pharmacology. | 2 |
| PLO11 | Yetkinlikler - Bağımsız Çalışabilme ve Sorumluluk Alabilme Yetkinliği | Have the ability to take part in in vitro/in vivo animal studies. |
Week Plan
| Week | Topic | Preparation | Methods |
|---|---|---|---|
| 1 | Introduction to individualized pharmacotherapy and basic concepts. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım |
| 2 | Inter-individual variability in pharmacotherapy | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım |
| 3 | Dose individualization based on pharmacokinetics. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım |
| 4 | Pharmacodynamics and variability in clinical response. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 5 | Therapeutic drug monitoring (TDM): basic principles | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım |
| 6 | Individualized approach in drugs with narrow therapeutic ranges. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 7 | Case analysis of drugs with narrow therapeutic ranges | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma |
| 8 | Mid-Term Exam | Review of suggested resources Review of relevant literature | Ölçme Yöntemleri: Yazılı Sınav |
| 9 | Pharmacogenetic and pharmacogenomic applications | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım |
| 10 | Individualized treatment approaches in special populations. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 11 | Dose individualization in renal failure. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Örnek Olay |
| 12 | Pharmacotherapy management in liver failure. | Pharmacotherapy management in liver failure. | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma, Örnek Olay |
| 13 | Individualized pharmacotherapy for critically ill patients. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım, Soru-Cevap, Tartışma |
| 14 | Patient-based assessment of drug interactions. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Anlatım, Tartışma, Örnek Olay, Problem Çözme |
| 15 | The use of artificial intelligence and clinical decision support systems in pharmacotherapy. | Review of suggested resources Review of relevant literature | Öğretim Yöntemleri: Soru-Cevap, Tartışma, Alıştırma ve Uygulama |
| 16 | Term Exams | Review of suggested resources Review of relevant literature | Ölçme Yöntemleri: Yazılı Sınav |
| 17 | Term Exams | Review of suggested resources Review of relevant literature | Ölçme Yöntemleri: Yazılı Sınav |
Student Workload - ECTS
| Works | Number | Time (Hour) | Workload (Hour) |
|---|---|---|---|
| Course Related Works | |||
| Class Time (Exam weeks are excluded) | 14 | 2 | 28 |
| Out of Class Study (Preliminary Work, Practice) | 14 | 2 | 28 |
| Assesment Related Works | |||
| Homeworks, Projects, Others | 0 | 0 | 0 |
| Mid-term Exams (Written, Oral, etc.) | 1 | 8 | 8 |
| Final Exam | 1 | 8 | 8 |
| Total Workload (Hour) | 72 | ||
| Total Workload / 25 (h) | 2,88 | ||
| ECTS | 3 ECTS | ||